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MC1R Antibody - C-terminal region
Rabbit Polyclonal Antibody
- 产品详情
- 实验流程
Application 
| WB |
|---|---|
| Primary Accession | Q01726 |
| Other Accession | NM_002386, NP_002377 |
| Reactivity | Human, Mouse, Rat, Rabbit, Pig |
| Predicted | Human, Mouse, Rat, Rabbit, Pig |
| Host | Rabbit |
| Clonality | Polyclonal |
| Calculated MW | 34706 Da |
| Gene ID | 4157 |
|---|---|
| Alias Symbol | CMM5, MGC14337, MSH-R, SHEP2 |
| Other Names | Melanocyte-stimulating hormone receptor, MSH-R, Melanocortin receptor 1, MC1-R, MC1R, MSHR |
| Format | Liquid. Purified antibody supplied in 1x PBS buffer with 0.09% (w/v) sodium azide and 2% sucrose. |
| Reconstitution & Storage | Add 50 ul of distilled water. Final anti-MC1R antibody concentration is 1 mg/ml in PBS buffer with 2% sucrose. For longer periods of storage, store at 20°C. Avoid repeat freeze-thaw cycles. |
| Precautions | MC1R Antibody - C-terminal region is for research use only and not for use in diagnostic or therapeutic procedures. |
| Name | MC1R (HGNC:6929) |
|---|---|
| Synonyms | MSHR |
| Function | G protein-coupled receptor that binds melanocyte-stimulating hormones (alpha, beta, and gamma-MSH) and adrenocorticotropic hormone/ACTH, which are peptide products of the POMC precursor protein (PubMed:11442765, PubMed:11707265, PubMed:1325670, PubMed:1516719, PubMed:8463333). Upon activation, MC1R couples with the G(s) protein, stimulating adenylate cyclase and activating the cAMP-dependent signaling pathway. This activation promotes melanogenesis, resulting in the production of eumelanin (black/brown) and pheomelanin (red/yellow) in melanocytes (PubMed:11707265, PubMed:1325670, PubMed:16463023, PubMed:19737927, PubMed:31097585, PubMed:34453129). MC1R interacts with G protein-coupled receptor opsin 3/OPN3, which couples to G(i) proteins and inhibits the alpha-MSH-induced cAMP response, thereby reducing melanin synthesis (PubMed:31097585). Binding to Agouti/ASP precludes alpha-MSH-induced signaling, thereby downregulating melanogenesis (By similarity). Additionally, interaction with MGRN1 displaces the G(s) protein, further suppressing MC1R signaling (PubMed:19737927). |
| Cellular Location | Cell membrane; Multi-pass membrane protein |
| Tissue Location | Expressed in melanocytes (PubMed:1325670, PubMed:31097585). Expressed in corticoadrenal tissue (PubMed:1325670) |
Research Areas
For Research Use Only. Not For Use In Diagnostic Procedures.
Application Protocols
Provided below are standard protocols that you may find useful for product applications.
REFERENCES
Mountjoy K.G.,et al.Science 257:1248-1251(1992).
Gantz I.,et al.J. Biol. Chem. 268:8246-8250(1993).
Chhajlani V.,et al.FEBS Lett. 309:417-420(1992).
Chhajlani V.,et al.FEBS Lett. 390:238-238(1996).
Rana B.K.,et al.Genetics 151:1547-1557(1999).
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