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>   首页   >   产品   >   一抗   >   癌症   >   ITGA5 antibody - C-terminal region   

ITGA5 antibody - C-terminal region

Rabbit Polyclonal Antibody

     
  • 1 - ITGA5 antibody - C-terminal region AI15129

    WB Suggested Anti-ITGA5 Antibody Titration: 1.0 μg/ml
    Positive Control: MDA-MB-435S Whole Cell
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Product Information
Application
  • Applications Legend:
  • E=ELISA
  • WB=Western Blotting
  • IHC=Immunohistochemistry
  • IHC-P=Immunohistochemistry (Paraffin)
  • IP=Immunoprecipitation
  • IF=Immunofluorescence
  • IC=Immunochemistry
  • ICC=Immunocytochemistry
  • FC=Flow Cytometry
  • DB=Dot Blot
WB
Primary Accession P08648
Other Accession NM_002205, NP_002196
Reactivity Human, Mouse
Predicted Human, Mouse
Host Rabbit
Clonality Polyclonal
Calculated MW 114536 Da
Additional Information
Gene ID 3678
Alias Symbol CD49e, FNRA, VLA5A
Other Names Integrin alpha-5, CD49 antigen-like family member E, Fibronectin receptor subunit alpha, Integrin alpha-F, VLA-5, CD49e, Integrin alpha-5 heavy chain, Integrin alpha-5 light chain, ITGA5, FNRA
Format Liquid. Purified antibody supplied in 1x PBS buffer with 0.09% (w/v) sodium azide and 2% sucrose.
Reconstitution & Storage Add 50 ul of distilled water. Final anti-ITGA5 antibody concentration is 1 mg/ml in PBS buffer with 2% sucrose. For longer periods of storage, store at 20°C. Avoid repeat freeze-thaw cycles.
PrecautionsITGA5 antibody - C-terminal region is for research use only and not for use in diagnostic or therapeutic procedures.
Protein Information
Name ITGA5 (HGNC:6141)
Synonyms FNRA
Function Integrin alpha-5/beta-1 (ITGA5:ITGB1) is a receptor for fibronectin and fibrinogen. It recognizes the sequence R-G-D in its ligands. ITGA5:ITGB1 binds to PLA2G2A via a site (site 2) which is distinct from the classical ligand-binding site (site 1) and this induces integrin conformational changes and enhanced ligand binding to site 1 (PubMed:18635536, PubMed:25398877). ITGA5:ITGB1 acts as a receptor for fibrillin-1 (FBN1) and mediates R-G-D-dependent cell adhesion to FBN1 (PubMed:12807887, PubMed:17158881). ITGA5:ITGB1 acts as a receptor for fibronectin (FN1) and mediates R-G-D-dependent cell adhesion to FN1 (PubMed:33962943). ITGA5:ITGB1 is a receptor for IL1B and binding is essential for IL1B signaling (PubMed:29030430). ITGA5:ITGB3 is a receptor for soluble CD40LG and is required for CD40/CD40LG signaling (PubMed:31331973).
Cellular Location Cell membrane; Single-pass type I membrane protein. Cell junction, focal adhesion
Tissue Location Expressed in placenta (at protein level).
Research Areas

For Research Use Only. Not For Use In Diagnostic Procedures.

REFERENCES

Argraves W.S.,et al.J. Cell Biol. 105:1183-1190(1987).
Birkenmeier T.M.,et al.J. Biol. Chem. 266:20544-20549(1991).
Fitzgerald L.A.,et al.Biochemistry 26:8158-8165(1987).
Argraves W.S.,et al.J. Biol. Chem. 261:12922-12924(1986).
Takada Y.,et al.Proc. Natl. Acad. Sci. U.S.A. 84:3239-3243(1987).

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