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EIF3J antibody - N-terminal region
Rabbit Polyclonal Antibody
- 产品详情
- 实验流程
Application 
| WB |
|---|---|
| Primary Accession | O75822 |
| Other Accession | NM_003758, NP_003749 |
| Reactivity | Human, Mouse, Rat, Rabbit, Zebrafish, Pig, Dog, Horse, Bovine |
| Predicted | Human, Mouse, Rat, Rabbit, Zebrafish, Pig, Dog, Horse, Bovine |
| Host | Rabbit |
| Clonality | Polyclonal |
| Calculated MW | 29062 Da |
| Gene ID | 8669 |
|---|---|
| Alias Symbol | EIF3S1, eIF3-alpha, eIF3-p35 |
| Other Names | Eukaryotic translation initiation factor 3 subunit J {ECO:0000255|HAMAP-Rule:MF_03009}, eIF3j {ECO:0000255|HAMAP-Rule:MF_03009}, Eukaryotic translation initiation factor 3 subunit 1 {ECO:0000255|HAMAP-Rule:MF_03009}, eIF-3-alpha {ECO:0000255|HAMAP-Rule:MF_03009}, eIF3 p35 {ECO:0000255|HAMAP-Rule:MF_03009}, EIF3J {ECO:0000255|HAMAP-Rule:MF_03009} |
| Format | Liquid. Purified antibody supplied in 1x PBS buffer with 0.09% (w/v) sodium azide and 2% sucrose. |
| Reconstitution & Storage | Add 50 ul of distilled water. Final anti-EIF3J antibody concentration is 1 mg/ml in PBS buffer with 2% sucrose. For longer periods of storage, store at 20°C. Avoid repeat freeze-thaw cycles. |
| Precautions | EIF3J antibody - N-terminal region is for research use only and not for use in diagnostic or therapeutic procedures. |
| Name | EIF3J {ECO:0000255|HAMAP-Rule:MF_03009} |
|---|---|
| Function | Component of the eukaryotic translation initiation factor 3 (eIF-3) complex, which is required for several steps in the initiation of protein synthesis (PubMed:25849773, PubMed:27462815). The eIF-3 complex associates with the 40S ribosome and facilitates the recruitment of eIF-1, eIF-1A, eIF-2:GTP:methionyl-tRNAi and eIF-5 to form the 43S pre-initiation complex (43S PIC). The eIF-3 complex stimulates mRNA recruitment to the 43S PIC and scanning of the mRNA for AUG recognition. The eIF-3 complex is also required for disassembly and recycling of post-termination ribosomal complexes and subsequently prevents premature joining of the 40S and 60S ribosomal subunits prior to initiation. The eIF-3 complex specifically targets and initiates translation of a subset of mRNAs involved in cell proliferation, including cell cycling, differentiation and apoptosis, and uses different modes of RNA stem-loop binding to exert either translational activation or repression (PubMed:25849773). |
| Cellular Location | Cytoplasm {ECO:0000255|HAMAP-Rule:MF_03009}. |
Research Areas
For Research Use Only. Not For Use In Diagnostic Procedures.
Application Protocols
Provided below are standard protocols that you may find useful for product applications.
REFERENCES
Block K.L.,et al.J. Biol. Chem. 273:31901-31908(1998).
Ota T.,et al.Nat. Genet. 36:40-45(2004).
Li W.B.,et al.Submitted (JUL-2004) to the EMBL/GenBank/DDBJ databases.
Zody M.C.,et al.Nature 440:671-675(2006).
Bienvenut W.V.,et al.Submitted (MAR-2008) to UniProtKB.
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