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ADI1 Antibody - N-terminal region
Rabbit Polyclonal Antibody
- 产品详情
- 实验流程
Application 
| WB |
|---|---|
| Primary Accession | Q9BV57 |
| Other Accession | NM_018269, NP_060739 |
| Reactivity | Human, Mouse, Rat, Rabbit, Zebrafish, Pig, Dog, Guinea Pig, Horse, Bovine |
| Predicted | Human, Mouse, Rat, Rabbit, Zebrafish, Pig, Dog, Guinea Pig, Horse, Bovine |
| Host | Rabbit |
| Clonality | Polyclonal |
| Calculated MW | 21498 Da |
| Gene ID | 55256 |
|---|---|
| Alias Symbol | APL1, ARD, FLJ10913, HMFT1638, MTCBP-1, MTCBP1, SIP-L, SIPL |
| Other Names | 1, 2-dihydroxy-3-keto-5-methylthiopentene dioxygenase {ECO:0000255|HAMAP-Rule:MF_03154}, 1.13.11.54 {ECO:0000255|HAMAP-Rule:MF_03154}, Acireductone dioxygenase (Fe(2+)-requiring) {ECO:0000255|HAMAP-Rule:MF_03154}, ARD {ECO:0000255|HAMAP-Rule:MF_03154}, Fe-ARD {ECO:0000255|HAMAP-Rule:MF_03154}, Membrane-type 1 matrix metalloproteinase cytoplasmic tail-binding protein 1 {ECO:0000255|HAMAP-Rule:MF_03154}, MTCBP-1 {ECO:0000255|HAMAP-Rule:MF_03154}, Submergence-induced protein-like factor, Sip-L, ADI1 {ECO:0000255|HAMAP-Rule:MF_03154} |
| Format | Liquid. Purified antibody supplied in 1x PBS buffer with 0.09% (w/v) sodium azide and 2% sucrose. |
| Reconstitution & Storage | Add 50 ul of distilled water. Final anti-ADI1 antibody concentration is 1 mg/ml in PBS buffer with 2% sucrose. For longer periods of storage, store at 20°C. Avoid repeat freeze-thaw cycles. |
| Precautions | ADI1 Antibody - N-terminal region is for research use only and not for use in diagnostic or therapeutic procedures. |
For Research Use Only. Not For Use In Diagnostic Procedures.
| Name | ADI1 {ECO:0000255|HAMAP-Rule:MF_03154} |
|---|---|
| Function | Catalyzes 2 different reactions between oxygen and the acireductone 1,2-dihydroxy-3-keto-5-methylthiopentene (DHK-MTPene) depending upon the metal bound in the active site (By similarity). Fe- containing acireductone dioxygenase (Fe-ARD) produces formate and 2- keto-4-methylthiobutyrate (KMTB), the alpha-ketoacid precursor of methionine in the methionine recycle pathway (PubMed:15938715). Ni- containing acireductone dioxygenase (Ni-ARD) produces methylthiopropionate, carbon monoxide and formate, and does not lie on the methionine recycle pathway (By similarity). Also down-regulates cell migration mediated by MMP14 (PubMed:14718544). Necessary for hepatitis C virus replication in an otherwise non-permissive cell line (PubMed:11602742). |
| Cellular Location | Cytoplasm. Nucleus. Cell membrane; Peripheral membrane protein; Cytoplasmic side. Note=Localizes to the plasma membrane when complexed to MMP14. |
| Tissue Location | Detected in heart, colon, lung, stomach, brain, spleen, liver, skeletal muscle and kidney |
Research Areas
Application Protocols
Provided below are standard protocols that you may find useful for product applications.
REFERENCES
Uekita T.,et al.J. Biol. Chem. 279:12734-12743(2004).
Fan Y.X.,et al.Submitted (JUL-2003) to the EMBL/GenBank/DDBJ databases.
Yamada S.,et al.Oncogene 23:5901-5911(2004).
Ota T.,et al.Nat. Genet. 36:40-45(2004).
Suzuki Y.,et al.Submitted (APR-2005) to the EMBL/GenBank/DDBJ databases.
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