癌症的基本特征包括细胞增殖、血管生成、迁移、凋亡逃避机制和细胞永生等。找到癌症发生过程中这些通路的关键标记物和对应的抗体用于检测至关重要。
为您推荐一个泛素化位点预测神器——泛素化分析工具，可以为您的蛋白的泛素化位点作出预测和评分。
细胞自噬受体图形绘图工具为你的蛋白的细胞受体结合位点作出预测和评分，识别结合到自噬通路中的蛋白是非常重要的，便于让我们理解自噬在正常生理、病理过程中的作用，如发育、细胞分化、神经退化性疾病、压力条件下、感染和癌症。
LAGE3 Antibody - N-terminal region
Rabbit Polyclonal Antibody
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- 实验流程
- 背景知识
Application 
| WB |
|---|---|
| Primary Accession | Q14657 |
| Other Accession | NM_006014, NP_006005 |
| Reactivity | Human |
| Predicted | Human |
| Host | Rabbit |
| Clonality | Polyclonal |
| Calculated MW | 14804 Da |
| Gene ID | 8270 |
|---|---|
| Alias Symbol | CVG5, DXS9879E, DXS9951E, ESO3, ITBA2 |
| Other Names | EKC/KEOPS complex subunit LAGE3, L antigen family member 3, Protein ESO-3, Protein ITBA2, LAGE3, DXS9879E, ESO3, ITBA2 |
| Format | Liquid. Purified antibody supplied in 1x PBS buffer with 0.09% (w/v) sodium azide and 2% sucrose. |
| Reconstitution & Storage | Add 50 &mu, l of distilled water. Final Anti-LAGE3 antibody concentration is 1 mg/ml in PBS buffer with 2% sucrose. For longer periods of storage, store at -20°C. Avoid repeat freeze-thaw cycles. |
| Precautions | LAGE3 Antibody - N-terminal region is for research use only and not for use in diagnostic or therapeutic procedures. |
For Research Use Only. Not For Use In Diagnostic Procedures.
| Name | LAGE3 (HGNC:26058) |
|---|---|
| Function | Component of the EKC/KEOPS complex that is required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine (PubMed:22912744, PubMed:27903914). The complex is probably involved in the transfer of the threonylcarbamoyl moiety of threonylcarbamoyl-AMP (TC-AMP) to the N6 group of A37 (PubMed:22912744, PubMed:27903914). LAGE3 functions as a dimerization module for the complex (PubMed:22912744, PubMed:27903914). |
| Cellular Location | Cytoplasm. Nucleus |
| Tissue Location | Ubiquitous. |
Provided below are standard protocols that you may find useful for product applications.
BACKGROUND
Component of the EKC/KEOPS complex that is required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine. The complex is probably involved in the transfer of the threonylcarbamoyl moiety of threonylcarbamoyl-AMP (TC-AMP) to the N6 group of A37. LAGE3 functions as a dimerization module for the complex (By similarity).
REFERENCES
Ross M.T.,et al.Nature 434:325-337(2005).
Faranda S.,et al.Genomics 34:323-327(1996).
Alpen B.,et al.Gene 297:141-149(2002).
Burkard T.R.,et al.BMC Syst. Biol. 5:17-17(2011).
Costessi A.,et al.PLoS ONE 7:E42822-E42822(2012).
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