癌症的基本特征包括细胞增殖、血管生成、迁移、凋亡逃避机制和细胞永生等。找到癌症发生过程中这些通路的关键标记物和对应的抗体用于检测至关重要。
为您推荐一个泛素化位点预测神器——泛素化分析工具，可以为您的蛋白的泛素化位点作出预测和评分。
细胞自噬受体图形绘图工具为你的蛋白的细胞受体结合位点作出预测和评分，识别结合到自噬通路中的蛋白是非常重要的，便于让我们理解自噬在正常生理、病理过程中的作用，如发育、细胞分化、神经退化性疾病、压力条件下、感染和癌症。
SMARCAL1 Antibody - N-terminal region
Rabbit Polyclonal Antibody
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Application 
| WB |
|---|---|
| Primary Accession | Q9NZC9 |
| Other Accession | XP_005246689 |
| Reactivity | Human |
| Predicted | Human |
| Host | Rabbit |
| Clonality | Polyclonal |
| Calculated MW | 105938 Da |
| Gene ID | 50485 |
|---|---|
| Alias Symbol | SMARCAL1, HARP, |
| Other Names | SWI/SNF-related matrix-associated actin-dependent regulator of chromatin subfamily A-like protein 1, 3.6.4.-, HepA-related protein, hHARP, Sucrose nonfermenting protein 2-like 1, SMARCAL1, HARP |
| Format | Liquid. Purified antibody supplied in 1x PBS buffer with 0.09% (w/v) sodium azide and 2% sucrose. |
| Reconstitution & Storage | Add 50 &mu, l of distilled water. Final Anti-SMARCAL1 antibody concentration is 1 mg/ml in PBS buffer with 2% sucrose. For longer periods of storage, store at -20°C. Avoid repeat freeze-thaw cycles. |
| Precautions | SMARCAL1 Antibody - N-terminal region is for research use only and not for use in diagnostic or therapeutic procedures. |
| Name | SMARCAL1 (HGNC:11102) |
|---|---|
| Function | ATP-dependent annealing helicase that binds selectively to fork DNA relative to ssDNA or dsDNA and catalyzes the rewinding of the stably unwound DNA. Rewinds single-stranded DNA bubbles that are stably bound by replication protein A (RPA). Acts throughout the genome to reanneal stably unwound DNA, performing the opposite reaction of many enzymes, such as helicases and polymerases, that unwind DNA. May play an important role in DNA damage response by acting at stalled replication forks. |
| Cellular Location | Nucleus Note=Recruited to damaged DNA regions |
| Tissue Location | Ubiquitously expressed, with high levels in testis. |
For Research Use Only. Not For Use In Diagnostic Procedures.
Provided below are standard protocols that you may find useful for product applications.
BACKGROUND
ATP-dependent annealing helicase that binds selectively to fork DNA relative to ssDNA or dsDNA and catalyzes the rewinding of the stably unwound DNA. Rewinds single-stranded DNA bubbles that are stably bound by replication protein A (RPA). Acts throughout the genome to reanneal stably unwound DNA, performing the opposite reaction of many enzymes, such as helicases and polymerases, that unwind DNA. May play an important role in DNA damage response by acting at stalled replication forks.
REFERENCES
Coleman M.A.,et al.Genomics 65:274-282(2000).
Boerkoel C.F.,et al.Nat. Genet. 30:215-220(2002).
Hillier L.W.,et al.Nature 434:724-731(2005).
Mural R.J.,et al.Submitted (JUL-2005) to the EMBL/GenBank/DDBJ databases.
Bechtel S.,et al.BMC Genomics 8:399-399(2007).
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