癌症的基本特征包括细胞增殖、血管生成、迁移、凋亡逃避机制和细胞永生等。找到癌症发生过程中这些通路的关键标记物和对应的抗体用于检测至关重要。
为您推荐一个泛素化位点预测神器——泛素化分析工具，可以为您的蛋白的泛素化位点作出预测和评分。
细胞自噬受体图形绘图工具为你的蛋白的细胞受体结合位点作出预测和评分，识别结合到自噬通路中的蛋白是非常重要的，便于让我们理解自噬在正常生理、病理过程中的作用，如发育、细胞分化、神经退化性疾病、压力条件下、感染和癌症。
BMPR1A Antibody - N-terminal region
Rabbit Polyclonal Antibody
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- 背景知识
Application 
| WB |
|---|---|
| Primary Accession | P36894 |
| Other Accession | XP_005270121 |
| Reactivity | Human |
| Host | Rabbit |
| Clonality | Polyclonal |
| Calculated MW | 60198 Da |
| Gene ID | 657 |
|---|---|
| Alias Symbol | BMPR1A, ACVRLK3, ALK3, |
| Other Names | Bone morphogenetic protein receptor type-1A, BMP type-1A receptor, BMPR-1A, 2.7.11.30, Activin receptor-like kinase 3, ALK-3, Serine/threonine-protein kinase receptor R5, SKR5, CD292, BMPR1A, ACVRLK3, ALK3 |
| Format | Liquid. Purified antibody supplied in 1x PBS buffer with 0.09% (w/v) sodium azide and 2% sucrose. |
| Reconstitution & Storage | Add 50 &mu, l of distilled water. Final Anti-BMPR1A antibody concentration is 1 mg/ml in PBS buffer with 2% sucrose. For longer periods of storage, store at -20°C. Avoid repeat freeze-thaw cycles. |
| Precautions | BMPR1A Antibody - N-terminal region is for research use only and not for use in diagnostic or therapeutic procedures. |
| Name | BMPR1A |
|---|---|
| Synonyms | ACVRLK3, ALK3 |
| Function | On ligand binding, forms a receptor complex consisting of two type II and two type I transmembrane serine/threonine kinases. Type II receptors phosphorylate and activate type I receptors which autophosphorylate, then bind and activate SMAD transcriptional regulators. Receptor for BMP2, BMP4, GDF5 and GDF6. Positively regulates chondrocyte differentiation through GDF5 interaction. Mediates induction of adipogenesis by GDF6. May promote the expression of HAMP, potentially via its interaction with BMP2 (By similarity). |
| Cellular Location | Cell membrane; Single-pass type I membrane protein. Cell surface {ECO:0000250|UniProtKB:P36895} |
| Tissue Location | Highly expressed in skeletal muscle. |
For Research Use Only. Not For Use In Diagnostic Procedures.
Provided below are standard protocols that you may find useful for product applications.
BACKGROUND
On ligand binding, forms a receptor complex consisting of two type II and two type I transmembrane serine/threonine kinases. Type II receptors phosphorylate and activate type I receptors which autophosphorylate, then bind and activate SMAD transcriptional regulators. Receptor for BMP-2 and BMP-4.
REFERENCES
ten Dijke P.,et al.Oncogene 8:2879-2887(1993).
Ota T.,et al.Nat. Genet. 36:40-45(2004).
Mahlawat P.,et al.Biochemistry 51:6328-6341(2012).
Kirsch T.,et al.Nat. Struct. Biol. 7:492-496(2000).
Howe J.R.,et al.Nat. Genet. 28:184-187(2001).
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