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>   首页   >   产品   >   一抗   >   癌症   >   EPCAM Antibody - N-terminal region   

EPCAM Antibody - N-terminal region

Rabbit Polyclonal Antibody

     
  • 1 - EPCAM Antibody - N-terminal region AI16102

    Host: Rabbit
    Target Name: EPCAM
    Sample Tissue: 786-0 Whole cell lysate
    s
    Antibody Dilution: 1.0μg/ml
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Product Information
Application
  • Applications Legend:
  • E=ELISA
  • WB=Western Blotting
  • IHC=Immunohistochemistry
  • IHC-P=Immunohistochemistry (Paraffin)
  • IP=Immunoprecipitation
  • IF=Immunofluorescence
  • IC=Immunochemistry
  • ICC=Immunocytochemistry
  • FC=Flow Cytometry
  • DB=Dot Blot
WB
Primary Accession P16422
Other Accession NP_002345
Reactivity Human
Host Rabbit
Clonality Polyclonal
Calculated MW 34932 Da
Additional Information
Gene ID 4072
Alias Symbol EPCAM, GA733-2, M1S2, M4S1, MIC18, TACSTD1, TROP1,
Other Names Epithelial cell adhesion molecule, Ep-CAM, Adenocarcinoma-associated antigen, Cell surface glycoprotein Trop-1, Epithelial cell surface antigen, Epithelial glycoprotein, EGP, Epithelial glycoprotein 314, EGP314, hEGP314, KS 1/4 antigen, KSA, Major gastrointestinal tumor-associated protein GA733-2, Tumor-associated calcium signal transducer 1, CD326, EPCAM, GA733-2, M1S2, M4S1, MIC18, TACSTD1, TROP1
Format Liquid. Purified antibody supplied in 1x PBS buffer with 0.09% (w/v) sodium azide and 2% sucrose.
Reconstitution & Storage Add 50 &mu, l of distilled water. Final Anti-EPCAM antibody concentration is 1 mg/ml in PBS buffer with 2% sucrose. For longer periods of storage, store at -20°C. Avoid repeat freeze-thaw cycles.
PrecautionsEPCAM Antibody - N-terminal region is for research use only and not for use in diagnostic or therapeutic procedures.
Protein Information
Name EPCAM
Synonyms GA733-2, M1S2, M4S1, MIC18, TACSTD1, TRO
Function May act as a physical homophilic interaction molecule between intestinal epithelial cells (IECs) and intraepithelial lymphocytes (IELs) at the mucosal epithelium for providing immunological barrier as a first line of defense against mucosal infection. Plays a role in embryonic stem cells proliferation and differentiation. Up-regulates the expression of FABP5, MYC and cyclins A and E.
Cellular Location Lateral cell membrane; Single-pass type I membrane protein. Cell junction, tight junction. Note=Colocalizes with CLDN7 at the lateral cell membrane and tight junction
Tissue Location Highly and selectively expressed by undifferentiated rather than differentiated embryonic stem cells (ESC) Levels rapidly diminish as soon as ESC's differentiate (at protein levels). Expressed in almost all epithelial cell membranes but not on mesodermal or neural cell membranes. Found on the surface of adenocarcinoma.
Research Areas

For Research Use Only. Not For Use In Diagnostic Procedures.

BACKGROUND

May act as a physical homophilic interaction molecule between intestinal epithelial cells (IECs) and intraepithelial lymphocytes (IELs) at the mucosal epithelium for providing immunological barrier as a first line of defense against mucosal infection. Plays a role in embryonic stem cells proliferation and differentiation. Up-regulates the expression of FABP5, MYC and cyclins A and E.

REFERENCES

Strnad J.,et al.Cancer Res. 49:314-317(1989).
Perez M.S.,et al.J. Immunol. 142:3662-3667(1989).
Simon B.,et al.Proc. Natl. Acad. Sci. U.S.A. 87:2755-2759(1990).
Szala S.,et al.Proc. Natl. Acad. Sci. U.S.A. 87:3542-3546(1990).
Linnenbach A.J.,et al.Mol. Cell. Biol. 13:1507-1515(1993).

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