癌症的基本特征包括细胞增殖、血管生成、迁移、凋亡逃避机制和细胞永生等。找到癌症发生过程中这些通路的关键标记物和对应的抗体用于检测至关重要。
为您推荐一个泛素化位点预测神器——泛素化分析工具，可以为您的蛋白的泛素化位点作出预测和评分。
细胞自噬受体图形绘图工具为你的蛋白的细胞受体结合位点作出预测和评分，识别结合到自噬通路中的蛋白是非常重要的，便于让我们理解自噬在正常生理、病理过程中的作用，如发育、细胞分化、神经退化性疾病、压力条件下、感染和癌症。
AL9A1 Antibody - C-terminal region
Rabbit Polyclonal Antibody
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Application 
| WB |
|---|---|
| Primary Accession | P49189 |
| Reactivity | Human |
| Host | Rabbit |
| Clonality | Polyclonal |
| Calculated MW | 53802 Da |
| Gene ID | 223 |
|---|---|
| Alias Symbol | ALDH9A1, ALDH4, ALDH7, ALDH9, |
| Other Names | 4-trimethylaminobutyraldehyde dehydrogenase, TMABADH, 1.2.1.47, Aldehyde dehydrogenase E3 isozyme, Aldehyde dehydrogenase family 9 member A1, 1.2.1.3, Gamma-aminobutyraldehyde dehydrogenase, 1.2.1.19, R-aminobutyraldehyde dehydrogenase, ALDH9A1, ALDH4, ALDH7, ALDH9 |
| Format | Liquid. Purified antibody supplied in 1x PBS buffer with 0.09% (w/v) sodium azide and 2% sucrose. |
| Reconstitution & Storage | Add 50 &mu, l of distilled water. Final Anti-AL9A1 antibody concentration is 1 mg/ml in PBS buffer with 2% sucrose. For longer periods of storage, store at -20°C. Avoid repeat freeze-thaw cycles. |
| Precautions | AL9A1 Antibody - C-terminal region is for research use only and not for use in diagnostic or therapeutic procedures. |
| Name | ALDH9A1 |
|---|---|
| Synonyms | ALDH4, ALDH7, ALDH9 {ECO:0000303|PubMed: |
| Function | Converts gamma-trimethylaminobutyraldehyde into gamma- butyrobetaine with high efficiency (in vitro). Can catalyze the irreversible oxidation of a broad range of aldehydes to the corresponding acids in an NAD-dependent reaction, but with low efficiency. Catalyzes the oxidation of aldehydes arising from biogenic amines and polyamines. |
| Cellular Location | Cytoplasm, cytosol {ECO:0000250|UniProtKB:Q9JLJ3}. Cytoplasm |
| Tissue Location | Detected in brain (at protein level) (PubMed:8645224). High expression in adult liver, skeletal muscle, and kidney. Low levels in heart, pancreas, lung and brain (PubMed:8786138) Expressed in all regions of the brain. Expression levels are variable in the different brain areas, with the highest levels in the spinal cord and the lowest in the occipital pole. |
For Research Use Only. Not For Use In Diagnostic Procedures.
Provided below are standard protocols that you may find useful for product applications.
BACKGROUND
Converts gamma-trimethylaminobutyraldehyde into gamma- butyrobetaine. Catalyzes the irreversible oxidation of a broad range of aldehydes to the corresponding acids in an NAD-dependent reaction.
REFERENCES
Lin S.W.,et al.Genomics 34:376-380(1996).
Vaz F.M.,et al.J. Biol. Chem. 275:7390-7394(2000).
Ota T.,et al.Nat. Genet. 36:40-45(2004).
Gregory S.G.,et al.Nature 441:315-321(2006).
Bienvenut W.V.,et al.Submitted (MAR-2008) to UniProtKB.
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