HTR7 antibody - N-terminal region

Rabbit Polyclonal Antibody

Product Information
Application Applications Legend: E=ELISA WB=Western Blotting IHC=Immunohistochemistry IHC-P=Immunohistochemistry (Paraffin) IP=Immunoprecipitation IF=Immunofluorescence IC=Immunochemistry ICC=Immunocytochemistry FC=Flow Cytometry DB=Dot Blot	WB
Primary Accession	P34969
Other Accession	NM_000872, NP_000863
Reactivity	Human, Mouse, Rat, Pig, Dog, Horse
Predicted	Human, Mouse, Rat, Pig, Dog, Horse
Host	Rabbit
Clonality	Polyclonal
Calculated MW	53555 Da

Additional Information
Gene ID	3363
Alias Symbol	5-HT7
Other Names	5-hydroxytryptamine receptor 7, 5-HT-7, 5-HT7, 5-HT-X, Serotonin receptor 7, HTR7
Format	Liquid. Purified antibody supplied in 1x PBS buffer with 0.09% (w/v) sodium azide and 2% sucrose.
Reconstitution & Storage	Add 100 ul of distilled water. Final anti-HTR7 antibody concentration is 1 mg/ml in PBS buffer with 2% sucrose. For longer periods of storage, store at 20°C. Avoid repeat freeze-thaw cycles.
Precautions	HTR7 antibody - N-terminal region is for research use only and not for use in diagnostic or therapeutic procedures.

Protein Information
Name	HTR7 {ECO:0000303\|Ref.3, ECO:0000312\|HGNC:HGNC:5302}
Function	G-protein coupled receptor for 5-hydroxytryptamine (serotonin), a biogenic hormone that functions as a neurotransmitter, a hormone and a mitogen (PubMed:35714614, PubMed:8226867). Ligand binding causes a conformation change that triggers signaling via guanine nucleotide-binding proteins (G proteins) and modulates the activity of downstream effectors (PubMed:35714614, PubMed:8226867). HTR7 is coupled to G(s) G alpha proteins and mediates activation of adenylate cyclase activity (PubMed:35714614).
Cellular Location	Cell membrane; Multi-pass membrane protein
Tissue Location	[Isoform A]: Predominant isoform in spleen, caudate and hippocampus. [Isoform D]: Minor isoform in terms of expression.