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STX1A antibody - N-terminal region
Rabbit Polyclonal Antibody
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Application 
| WB |
|---|---|
| Primary Accession | Q16623 |
| Other Accession | NM_004603, NP_004594 |
| Reactivity | Human, Mouse, Rat, Pig, Dog, Guinea Pig, Bovine |
| Predicted | Human, Mouse, Rat, Pig, Dog, Guinea Pig, Bovine |
| Host | Rabbit |
| Clonality | Polyclonal |
| Calculated MW | 33023 Da |
| Gene ID | 6804 |
|---|---|
| Alias Symbol | HPC-1, STX1, p35-1, P35-1, SYN1A |
| Other Names | Syntaxin-1A, Neuron-specific antigen HPC-1, STX1A, STX1 |
| Format | Liquid. Purified antibody supplied in 1x PBS buffer with 0.09% (w/v) sodium azide and 2% sucrose. |
| Reconstitution & Storage | Add 50 ul of distilled water. Final anti-STX1A antibody concentration is 1 mg/ml in PBS buffer with 2% sucrose. For longer periods of storage, store at 20°C. Avoid repeat freeze-thaw cycles. |
| Precautions | STX1A antibody - N-terminal region is for research use only and not for use in diagnostic or therapeutic procedures. |
| Name | STX1A |
|---|---|
| Synonyms | STX1 |
| Function | Plays an essential role in hormone and neurotransmitter calcium-dependent exocytosis and endocytosis (PubMed:26635000). Part of the SNARE (Soluble NSF Attachment Receptor) complex composed of SNAP25, STX1A and VAMP2 which mediates the fusion of synaptic vesicles with the presynaptic plasma membrane. STX1A and SNAP25 are localized on the plasma membrane while VAMP2 resides in synaptic vesicles. The pairing of the three SNAREs from the N-terminal SNARE motifs to the C-terminal anchors leads to the formation of the SNARE complex, which brings membranes into close proximity and results in final fusion. Participates in the calcium-dependent regulation of acrosomal exocytosis in sperm (PubMed:23091057). Also plays an important role in the exocytosis of hormones such as insulin or glucagon-like peptide 1 (GLP-1) (By similarity). |
| Cellular Location | Cytoplasmic vesicle, secretory vesicle, synaptic vesicle membrane {ECO:0000250|UniProtKB:O35526}; Single-pass type IV membrane protein {ECO:0000250|UniProtKB:O35526}. Synapse, synaptosome {ECO:0000250|UniProtKB:O35526}. Cell membrane {ECO:0000250|UniProtKB:P32851}. Note=Colocalizes with KCNB1 at the cell membrane. {ECO:0000250|UniProtKB:P32851} |
| Tissue Location | [Isoform 1]: Highly expressed in embryonic spinal cord and ganglia and in adult cerebellum and cerebral cortex |
For Research Use Only. Not For Use In Diagnostic Procedures.
Provided below are standard protocols that you may find useful for product applications.
BACKGROUND
Potentially involved in docking of synaptic vesicles at presynaptic active zones. May play a critical role in neurotransmitter exocytosis. May mediate Ca(2+)-regulation of exocytosis acrosomal reaction in sperm.
REFERENCES
Zhang R.-D.,et al.Gene 159:293-294(1995).
Osborne L.R.,et al.Am. J. Hum. Genet. 61:449-452(1997).
Wu Y.-Q.,et al.Am. J. Med. Genet. 109:121-124(2002).
Jagadish M.N.,et al.Biochem. J. 321:151-156(1997).
Nakayama T.,et al.Genomics 42:173-176(1997).
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