癌症的基本特征包括细胞增殖、血管生成、迁移、凋亡逃避机制和细胞永生等。找到癌症发生过程中这些通路的关键标记物和对应的抗体用于检测至关重要。
为您推荐一个泛素化位点预测神器——泛素化分析工具，可以为您的蛋白的泛素化位点作出预测和评分。
细胞自噬受体图形绘图工具为你的蛋白的细胞受体结合位点作出预测和评分，识别结合到自噬通路中的蛋白是非常重要的，便于让我们理解自噬在正常生理、病理过程中的作用，如发育、细胞分化、神经退化性疾病、压力条件下、感染和癌症。
NUCB1 antibody - C-terminal region
Rabbit Polyclonal Antibody
- 产品详情
- 实验流程
- 背景知识
Application 
| WB, IHC |
|---|---|
| Primary Accession | Q63083 |
| Other Accession | NM_053463.1, NP_445915 |
| Reactivity | Mouse, Rat, Dog |
| Predicted | Mouse, Rat, Dog |
| Host | Rabbit |
| Clonality | Polyclonal |
| Calculated MW | 53507 Da |
| Gene ID | 84595 |
|---|---|
| Alias Symbol | Nucb |
| Other Names | Nucleobindin-1, Bone 63 kDa calcium-binding protein, CALNUC, Nucb1, Nuc |
| Format | Liquid. Purified antibody supplied in 1x PBS buffer with 0.09% (w/v) sodium azide and 2% sucrose. |
| Reconstitution & Storage | Add 100 ul of distilled water. Final anti-NUCB1 antibody concentration is 1 mg/ml in PBS buffer with 2% sucrose. For longer periods of storage, store at 20°C. Avoid repeat freeze-thaw cycles. |
| Precautions | NUCB1 antibody - C-terminal region is for research use only and not for use in diagnostic or therapeutic procedures. |
For Research Use Only. Not For Use In Diagnostic Procedures.
| Name | Nucb1 |
|---|---|
| Synonyms | Nuc |
| Function | Major calcium-binding protein of the Golgi which may have a role in calcium homeostasis (PubMed:7890746). Acts as a non-receptor guanine nucleotide exchange factor which binds to and activates alpha subunits of guanine nucleotide-binding proteins (G proteins) (PubMed:21653697). |
| Cellular Location | Golgi apparatus, cis-Golgi network membrane; Peripheral membrane protein; Lumenal side. Cytoplasm. Secreted Note=A small fraction of the protein may be cytoplasmic. In bone at least part of it is found in the extracellular matrix and in the culture medium of calvaria explants. |
| Tissue Location | Minor constituent of the mineralized matrix of bone. Detected in calvaria, rib cartilage, liver, kidney, spleen, brain, lung, skeletal and heart muscle with highest expression in calvaria and approximately half the amount in kidney, liver and brain |
Provided below are standard protocols that you may find useful for product applications.
BACKGROUND
Major calcium-binding protein of the Golgi. May have a role in calcium homeostasis.
REFERENCES
Wendel M.,et al.J. Biol. Chem. 270:6125-6133(1995).
Long X.,et al.Submitted (JAN-2001) to the EMBL/GenBank/DDBJ databases.
Adams L.A.,et al.Submitted (OCT-1996) to the EMBL/GenBank/DDBJ databases.
Lin P.,et al.J. Cell Biol. 141:1515-1527(1998).
Lin P.,et al.Proc. Natl. Acad. Sci. U.S.A. 97:674-679(2000).
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