癌症的基本特征包括细胞增殖、血管生成、迁移、凋亡逃避机制和细胞永生等。找到癌症发生过程中这些通路的关键标记物和对应的抗体用于检测至关重要。
为您推荐一个泛素化位点预测神器——泛素化分析工具，可以为您的蛋白的泛素化位点作出预测和评分。
细胞自噬受体图形绘图工具为你的蛋白的细胞受体结合位点作出预测和评分，识别结合到自噬通路中的蛋白是非常重要的，便于让我们理解自噬在正常生理、病理过程中的作用，如发育、细胞分化、神经退化性疾病、压力条件下、感染和癌症。
Anti-DMN / Desmuslin / Synemin Antibody (aa329-580, clone 2F4)
Mouse Anti Human Monoclonal Antibody
- 产品详情
- 实验流程
Application 
| IHC-P |
|---|---|
| Primary Accession | O15061 |
| Predicted | Human |
| Host | Mouse |
| Clonality | Monoclonal |
| Isotype | IgG1 |
| Clone Names | 2F4 |
| Calculated MW | 172868 Da |
| Concentration (mg/ml) | 1 mg/ml |
| Gene ID | 23336 |
|---|---|
| Alias Symbol | SYNM |
| Other Names | SYNM, Desmuslin, KIAA0353, SYN, Synemin beta, Synemin, DMN, Synemin alpha |
| Target/Specificity | Human DMN / Desmuslin / Synemin |
| Reconstitution & Storage | PBS, pH 7.3, 1% BSA, 50% glycerol, 0.02% sodium azide Store at -20°C. Minimize freezing and thawing. |
| Precautions | Anti-DMN / Desmuslin / Synemin Antibody (aa329-580, clone 2F4) is for research use only and not for use in diagnostic or therapeutic procedures. |
For Research Use Only. Not For Use In Diagnostic Procedures.
| Name | SYNM (HGNC:24466) |
|---|---|
| Synonyms | DMN, KIAA0353, SYN |
| Function | Type-VI intermediate filament (IF) which plays an important cytoskeletal role within the muscle cell cytoskeleton. It forms heteromeric IFs with desmin and/or vimentin, and via its interaction with cytoskeletal proteins alpha-dystrobrevin, dystrophin, talin-1, utrophin and vinculin, is able to link these heteromeric IFs to adherens-type junctions, such as to the costameres, neuromuscular junctions, and myotendinous junctions within striated muscle cells. |
| Cellular Location | Cytoplasm, cytoskeleton. Cell junction, adherens junction. Note=There are at least two distinct SYNM subpopulations, one in which SYMN interacts with DES within the Z-lines, and another in which it interacts with both DTNA and DES at the costamere |
| Tissue Location | Isoform 2 is strongly detected in adult heart, fetal skeletal muscles and fetal heart. Isoform 1 is weakly detected in fetal heart and also in fetal skeletal muscle. Isoform 1 and isoform 2 are detected in adult bladder (at protein level). The mRNA is predominantly expressed in heart and muscle with some expression in brain which may be due to tissue-specific isoforms |
Research Areas
Application Protocols
Provided below are standard protocols that you may find useful for product applications.
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