Anti-HNRNP-E2 / PCBP2 Antibody

Rabbit Anti Human Polyclonal Antibody

Product Information
Application Applications Legend: E=ELISA WB=Western Blotting IHC=Immunohistochemistry IHC-P=Immunohistochemistry (Paraffin) IP=Immunoprecipitation IF=Immunofluorescence IC=Immunochemistry ICC=Immunocytochemistry FC=Flow Cytometry DB=Dot Blot	WB, IHC-P, IF
Primary Accession	Q15366
Predicted	Human, Mouse, Rat
Host	Rabbit
Clonality	Polyclonal
Isotype	IgG
Calculated MW	38580 Da

Additional Information
Gene ID	5094
Alias Symbol	PCBP2
Other Names	PCBP2, Alpha-CP2, HnRNP E2, HNRPE2, Poly(rC) binding protein 2, Poly(rC)-binding protein 2, HnRNP-E2
Target/Specificity	Human HNRNP-E2 / PCBP2
Reconstitution & Storage	PBS, pH 7.3, 0.02% sodium azide, 50% glycerol. Long term: -80°C; Short term: -20°C. Avoid freeze-thaw cycles.
Precautions	Anti-HNRNP-E2 / PCBP2 Antibody is for research use only and not for use in diagnostic or therapeutic procedures.

Protein Information
Name	PCBP2 {ECO:0000303\|PubMed:7607214, ECO:0000312\|HGNC:HGNC:8648}
Function	Single-stranded nucleic acid binding protein that binds preferentially to oligo dC (PubMed:12414943, PubMed:7607214). Major cellular poly(rC)-binding protein (PubMed:12414943). Also binds poly(rU) (PubMed:12414943). Acts as a negative regulator of antiviral signaling (PubMed:19881509, PubMed:35322803). Negatively regulates cellular antiviral responses mediated by MAVS signaling (PubMed:19881509). It acts as an adapter between MAVS and the E3 ubiquitin ligase ITCH, therefore triggering MAVS ubiquitination and degradation (PubMed:19881509). Negativeley regulates the cGAS-STING pathway via interaction with CGAS, preventing the formation of liquid- like droplets in which CGAS is activated (PubMed:35322803). Together with PCBP1, required for erythropoiesis, possibly by regulating mRNA splicing (By similarity).
Cellular Location	Nucleus. Cytoplasm. Note=Loosely bound in the nucleus (PubMed:7607214). May shuttle between the nucleus and the cytoplasm (PubMed:7607214).
Tissue Location	Detected in all tissues examined.