Anti-TG / Thyroglobulin Antibody (clone 2H11)

Mouse Anti Human Monoclonal Antibody

Product Information
Application Applications Legend: E=ELISA WB=Western Blotting IHC=Immunohistochemistry IHC-P=Immunohistochemistry (Paraffin) IP=Immunoprecipitation IF=Immunofluorescence IC=Immunochemistry ICC=Immunocytochemistry FC=Flow Cytometry DB=Dot Blot	IHC-P
Primary Accession	P01266
Predicted	Human
Host	Mouse
Clonality	Monoclonal
Isotype	IgG1,k
Clone Names	2H11
Calculated MW	304790 Da
Concentration (mg/ml)	0.2 mg/ml

Additional Information
Gene ID	7038
Alias Symbol	TG
Other Names	TG, AITD3, TDH3, Thyroglobulin, TGN
Target/Specificity	Human TG / Thyroglobulin
Reconstitution & Storage	PBS, 0.05% sodium azide. Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze-thaw cycles.
Precautions	Anti-TG / Thyroglobulin Antibody (clone 2H11) is for research use only and not for use in diagnostic or therapeutic procedures.

Protein Information
Name	TG (HGNC:11764)
Function	Acts as a substrate for the production of iodinated thyroid hormones thyroxine (T4) and triiodothyronine (T3) (PubMed:17532758, PubMed:32025030). The synthesis of T3 and T4 involves iodination of selected tyrosine residues of TG/thyroglobulin followed by their oxidative coupling in the thyroid follicle lumen (PubMed:32025030). Following TG re-internalization and lysosomal-mediated proteolysis, T3 and T4 are released from the polypeptide backbone leading to their secretion into the bloodstream (PubMed:32025030). One dimer produces 7 thyroid hormone molecules (PubMed:32025030).
Cellular Location	Secreted. Note=Secreted into the thyroid follicle lumen (PubMed:19509106). Localizes to colloid globules, a structure formed in the thyroid follicle lumen consisting of cross-linked TG arranged in concentric layers (PubMed:11082042, PubMed:8626858).
Tissue Location	Specifically expressed in the thyroid gland.

Research Areas

For Research Use Only. Not For Use In Diagnostic Procedures.

Application Protocols

Provided below are standard protocols that you may find useful for product applications.

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Discontinued

Cat# ALS17384

Size:

250 µl

Price:

¥ 4,380.00

替代产品:

Thyroglobulin (Thyroidal Cell Marker) Antibody - With BSA and Azide, Thyroglobulin (Thyroidal Cell Marker) Antibody - With BSA and Azide, Thyroglobulin (Thyroidal Cell Marker) Antibody - With BSA and Azide,