Anti-DFNA5 Antibody (Internal)

Rabbit Anti Human Polyclonal Antibody

Product Information
Application Applications Legend: E=ELISA WB=Western Blotting IHC=Immunohistochemistry IHC-P=Immunohistochemistry (Paraffin) IP=Immunoprecipitation IF=Immunofluorescence IC=Immunochemistry ICC=Immunocytochemistry FC=Flow Cytometry DB=Dot Blot	WB, IHC-P
Primary Accession	O60443
Predicted	Human, Mouse, Rat
Host	Rabbit
Clonality	Polyclonal
Calculated MW	54555 Da
Concentration (mg/ml)	1 mg/ml

Additional Information
Gene ID	1687
Alias Symbol	DFNA5
Other Names	DFNA5, ICERE-1, Deafness, autosomal dominant 5, ICERE1
Target/Specificity	Recognizes endogenous levels of DFNA5 protein.
Reconstitution & Storage	PBS, pH 7.3, 0.01% sodium azide, 30% glycerol. Store at -20°C. Aliquot to avoid freeze/thaw cycles.
Precautions	Anti-DFNA5 Antibody (Internal) is for research use only and not for use in diagnostic or therapeutic procedures.

Protein Information
Name	GSDME {ECO:0000303\|PubMed:28459430, ECO:0000312\|HGNC:HGNC:2810}
Function	[Gasdermin-E]: Precursor of a pore-forming protein that converts non-inflammatory apoptosis to pyroptosis (PubMed:27281216, PubMed:28459430, PubMed:33852854, PubMed:35594856, PubMed:36607699). This form constitutes the precursor of the pore-forming protein: upon cleavage, the released N-terminal moiety (Gasdermin-E, N-terminal) binds to membranes and forms pores, triggering pyroptosis (PubMed:28459430).
Cellular Location	[Gasdermin-E, N-terminal]: Cell membrane; Multi-pass membrane protein {ECO:0000250\|UniProtKB:Q5Y4Y6}
Tissue Location	Expressed in cochlea (PubMed:9771715). Low level of expression in heart, brain, placenta, lung, liver, skeletal muscle, kidney and pancreas, with highest expression in placenta (PubMed:9771715).