Anti-CD19 Antibody (clone 3G7)

Mouse Anti Human Monoclonal Antibody

Product Information
Application Applications Legend: E=ELISA WB=Western Blotting IHC=Immunohistochemistry IHC-P=Immunohistochemistry (Paraffin) IP=Immunoprecipitation IF=Immunofluorescence IC=Immunochemistry ICC=Immunocytochemistry FC=Flow Cytometry DB=Dot Blot	WB, IHC-P, IF, FC
Primary Accession	P15391
Predicted	Human
Host	Mouse
Clonality	Monoclonal
Isotype	IgG1
Clone Names	3G7
Calculated MW	61128 Da
Concentration (mg/ml)	1 mg/ml

Additional Information
Gene ID	930
Alias Symbol	CD19
Other Names	CD19, B-lymphocyte antigen CD19, CD19 molecule, Differentiation antigen CD19, T-cell surface antigen Leu-12, B4, CD19 antigen, CVID3
Target/Specificity	Human CD19
Reconstitution & Storage	PBS, pH 7.3, 1% BSA, 50% glycerol, 0.02% sodium azide Store at -20°C. Minimize freezing and thawing.
Precautions	Anti-CD19 Antibody (clone 3G7) is for research use only and not for use in diagnostic or therapeutic procedures.

Protein Information
Name	CD19
Function	Functions as a coreceptor for the B-cell antigen receptor complex (BCR) on B-lymphocytes (PubMed:29523808). Decreases the threshold for activation of downstream signaling pathways and for triggering B-cell responses to antigens (PubMed:1373518, PubMed:16672701, PubMed:2463100). Activates signaling pathways that lead to the activation of phosphatidylinositol 3-kinase and the mobilization of intracellular Ca(2+) stores (PubMed:12387743, PubMed:16672701, PubMed:9317126, PubMed:9382888). Is not required for early steps during B cell differentiation in the blood marrow (PubMed:9317126). Required for normal differentiation of B-1 cells (By similarity). Required for normal B cell differentiation and proliferation in response to antigen challenges (PubMed:1373518, PubMed:2463100). Required for normal levels of serum immunoglobulins, and for production of high-affinity antibodies in response to antigen challenge (PubMed:12387743, PubMed:16672701, PubMed:9317126).
Cellular Location	Cell membrane; Single-pass type I membrane protein. Membrane raft {ECO:0000250\|UniProtKB:P25918}; Single-pass type I membrane protein {ECO:0000250\|UniProtKB:P25918}
Tissue Location	Detected on marginal zone and germinal center B cells in lymph nodes (PubMed:2463100). Detected on blood B cells (at protein level) (PubMed:16672701, PubMed:2463100)