癌症的基本特征包括细胞增殖、血管生成、迁移、凋亡逃避机制和细胞永生等。找到癌症发生过程中这些通路的关键标记物和对应的抗体用于检测至关重要。
为您推荐一个泛素化位点预测神器——泛素化分析工具，可以为您的蛋白的泛素化位点作出预测和评分。
细胞自噬受体图形绘图工具为你的蛋白的细胞受体结合位点作出预测和评分，识别结合到自噬通路中的蛋白是非常重要的，便于让我们理解自噬在正常生理、病理过程中的作用，如发育、细胞分化、神经退化性疾病、压力条件下、感染和癌症。
Anti-ADGRD1 / GPR133 Antibody (C-Terminus)
Rabbit Anti Human Polyclonal Antibody
- 产品详情
- 实验流程
Application 
| IHC-P |
|---|---|
| Primary Accession | Q6QNK2 |
| Predicted | Human |
| Host | Rabbit |
| Clonality | Polyclonal |
| Calculated MW | 96530 Da |
| Concentration (mg/ml) | 1 mg/ml |
| Gene ID | 283383 |
|---|---|
| Alias Symbol | ADGRD1 |
| Other Names | ADGRD1, G protein-coupled receptor 133, GPR133, PGR25 |
| Target/Specificity | Human GPR133. BLAST analysis of the peptide immunogen showed no homology with other human proteins. |
| Reconstitution & Storage | PBS, less than 0.1% sodium azide. Aliquot and store undiluted at -20°C or below for up to 1 year. Can be stored undiluted at 4°C for up to 1 month. Avoid freeze thaw cycles. |
| Precautions | Anti-ADGRD1 / GPR133 Antibody (C-Terminus) is for research use only and not for use in diagnostic or therapeutic procedures. |
For Research Use Only. Not For Use In Diagnostic Procedures.
| Name | ADGRD1 {ECO:0000303|PubMed:25713288, ECO:0000312|HGNC:HGNC:19893} |
|---|---|
| Function | Adhesion G protein-coupled receptor (aGPCR) for androgen hormone 5alpha-dihydrotestosterone (5alpha-DHT), also named 17beta- hydroxy-5alpha-androstan-3-one, the most potent hormone among androgens (PubMed:39884271). Also activated by methenolone drug (PubMed:39884271). Ligand binding causes a conformation change that triggers signaling via guanine nucleotide-binding proteins (G proteins) and modulates the activity of downstream effectors, such as adenylate cyclase (PubMed:39884271). ADGRD1 is coupled to G(s) G proteins and mediates activation of adenylate cyclase activity (PubMed:22025619, PubMed:22575658, PubMed:35447113, PubMed:39884271). Acts as a 5alpha- DHT receptor in muscle cells, thereby increasing intracellular cyclic AMP (cAMP) levels and enhancing muscle strength (PubMed:39884271). |
| Cellular Location | Cell membrane; Multi-pass membrane protein |
| Tissue Location | Up-regulated in CD133(+) cell population of glioblastoma. |
Research Areas
Application Protocols
Provided below are standard protocols that you may find useful for product applications.
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