癌症的基本特征包括细胞增殖、血管生成、迁移、凋亡逃避机制和细胞永生等。找到癌症发生过程中这些通路的关键标记物和对应的抗体用于检测至关重要。
为您推荐一个泛素化位点预测神器——泛素化分析工具，可以为您的蛋白的泛素化位点作出预测和评分。
细胞自噬受体图形绘图工具为你的蛋白的细胞受体结合位点作出预测和评分，识别结合到自噬通路中的蛋白是非常重要的，便于让我们理解自噬在正常生理、病理过程中的作用，如发育、细胞分化、神经退化性疾病、压力条件下、感染和癌症。
Anti-MCHR2 Antibody (Cytoplasmic Domain)
Rabbit Anti Human Polyclonal Antibody
- 产品详情
- 实验流程
Application 
| IHC-P |
|---|---|
| Primary Accession | Q969V1 |
| Predicted | Human, Monkey |
| Host | Rabbit |
| Clonality | Polyclonal |
| Calculated MW | 38849 Da |
| Concentration (mg/ml) | 1 mg/ml |
| Gene ID | 84539 |
|---|---|
| Alias Symbol | MCHR2 |
| Other Names | MCHR2, G protein-coupled receptor slt, GPRv17, GPR145, G protein-coupled receptor 145, G-protein coupled receptor 145, MCH receptor 2, MCHR-2, MCH-2R, MCH-R2, MCH2, Mch2 receptor, SLT receptor, MCH2R, SLT |
| Target/Specificity | Human MCHR2. BLAST analysis of the peptide immunogen showed no homology with other human proteins, except REEP4 (44%). |
| Reconstitution & Storage | Immunoaffinity purified |
| Precautions | Anti-MCHR2 Antibody (Cytoplasmic Domain) is for research use only and not for use in diagnostic or therapeutic procedures. |
For Research Use Only. Not For Use In Diagnostic Procedures.
| Name | MCHR2 (HGNC:20867) |
|---|---|
| Function | G protein-coupled receptor for the neuropeptide melanin- concentrating hormone (MCH). Upon ligand binding, couples to G(q/11), leading to activation of phospholipase C and intracellular calcium mobilization (PubMed:11274220, PubMed:11404457, PubMed:11459838, PubMed:15340116, PubMed:38710677). The physiological roles mediated by this receptor remain unclear, and its contribution to specific biological processes has not been conclusively established (Probable). Expression of this receptor is restricted to the brain of non-rodent mammals; a functional MCHR2 gene is absent or pseudogenized in rodents (By similarity). |
| Cellular Location | Cell membrane; Multi-pass membrane protein |
| Tissue Location | Specifically expressed in the brain (PubMed:11274220, PubMed:11355873, PubMed:11404457, PubMed:11459838) In the brain, highly expressed in cerebral cortex, hippocampus and amygdala (PubMed:11355873, PubMed:11459838). Also expressed in the arcuate nucleus and the ventral medial hypothalamus (PubMed:11404457) No expression detected in the cerebellum and thalamus (PubMed:11355873). |
Research Areas
Application Protocols
Provided below are standard protocols that you may find useful for product applications.
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