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>   首页   >   产品   >   一抗   >   心血管   >   Anti-GPR174 Antibody (Extracellular Domain)   

Anti-GPR174 Antibody (Extracellular Domain)

Rabbit Anti Human Polyclonal Antibody

     
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Product Information
Application
  • Applications Legend:
  • E=ELISA
  • WB=Western Blotting
  • IHC=Immunohistochemistry
  • IHC-P=Immunohistochemistry (Paraffin)
  • IP=Immunoprecipitation
  • IF=Immunofluorescence
  • IC=Immunochemistry
  • ICC=Immunocytochemistry
  • FC=Flow Cytometry
  • DB=Dot Blot
IHC-P
Primary Accession Q9BXC1
Predicted Human, Rabbit, Monkey
Host Rabbit
Clonality Polyclonal
Calculated MW 38503 Da
Concentration (mg/ml) 1 mg/ml
Additional Information
Gene ID 84636
Alias Symbol GPR174
Other Names GPR174, FKSG79, Jeg18, Purinergic receptor fksg79, G protein-coupled receptor 174
Target/Specificity Human GPR174. BLAST analysis of the peptide immunogen showed no homology with other human proteins, except RGAG1 (50%).
Reconstitution & Storage Immunoaffinity purified
PrecautionsAnti-GPR174 Antibody (Extracellular Domain) is for research use only and not for use in diagnostic or therapeutic procedures.
Protein Information
Name GPR174
Function G-protein-coupled receptor of lysophosphatidylserine (LysoPS) that plays different roles in immune response (PubMed:36823105). Plays a negative role in regulatory T-cell accumulation and homeostasis. Under inflammatory conditions where LysoPS production increases, contributes to the down-regulation of regulatory T-cell activity to favor effector response. Mediates the suppression of IL-2 production in activated T-lymphocytes leading to inhibition of growth, proliferation and differentiation of T-cells. Mechanistically, acts via G(s)- containing heterotrimeric G proteins to trigger elevated cyclic AMP levels and protein kinase A/PKA activity, which may in turn act to antagonize proximal TCR signaling. Plays an important role in the initial period of sepsis through the regulation of macrophage polarization and pro- and anti-inflammatory cytokine secretions. Upon testosterone treatment, acts as a receptor for CCL21 and subsequently triggers through G(q)-alpha and G(12)/G(13) proteins a calcium flux leading to chemotactic effects on activated B-cells. Signals via GNA13 and PKA to promote CD86 up-regulation by follicular B-cells.
Cellular Location Cell membrane; Multi-pass membrane protein.
Research Areas

For Research Use Only. Not For Use In Diagnostic Procedures.

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