Anti-GPR37L1 Antibody (C-Terminus)

Rabbit Anti Human Polyclonal Antibody

Product Information
Application Applications Legend: E=ELISA WB=Western Blotting IHC=Immunohistochemistry IHC-P=Immunohistochemistry (Paraffin) IP=Immunoprecipitation IF=Immunofluorescence IC=Immunochemistry ICC=Immunocytochemistry FC=Flow Cytometry DB=Dot Blot	IHC-P
Primary Accession	O60883
Predicted	Human
Host	Rabbit
Clonality	Polyclonal
Calculated MW	52771 Da
Concentration (mg/ml)	1 mg/ml

Additional Information
Gene ID	9283
Alias Symbol	GPR37L1
Other Names	GPR37L1, ETBRLP2, ET(B)R-LP-2, ETBR-LP-2, GPCR/CNS2
Target/Specificity	Human GPR37L1. BLAST analysis of the peptide immunogen showed no homology with other human proteins.
Reconstitution & Storage	Immunoaffinity purified
Precautions	Anti-GPR37L1 Antibody (C-Terminus) is for research use only and not for use in diagnostic or therapeutic procedures.

Protein Information
Name	GPR37L1
Synonyms	ETBRLP2
Function	G-protein coupled receptor (PubMed:27072655). Has been shown to bind the neuroprotective and glioprotective factor prosaposin (PSAP), leading to endocytosis followed by an ERK phosphorylation cascade (PubMed:23690594). However, other studies have shown that prosaposin does not increase activity (PubMed:27072655, PubMed:28688853). It has been suggested that GPR37L1 is a constitutively active receptor which signals through the guanine nucleotide-binding protein G(s) subunit alpha (PubMed:27072655). Participates in the regulation of postnatal cerebellar development by modulating the Shh pathway (By similarity). Regulates baseline blood pressure in females and protects against cardiovascular stress in males (By similarity). Mediates inhibition of astrocyte glutamate transporters and reduction in neuronal N-methyl-D-aspartate receptor activity (By similarity).
Cellular Location	Cell membrane; Multi-pass membrane protein. Cell projection, cilium membrane {ECO:0000250\|UniProtKB:Q99JG2}; Multi-pass membrane protein. Note=Associates with the basal membrane of Bergmann glia cell primary cilia. {ECO:0000250\|UniProtKB:Q99JG2}
Tissue Location	Expressed in primary cortical astrocytes (at protein level) (PubMed:23690594). Expressed in the central nervous system (PubMed:9539149).