癌症的基本特征包括细胞增殖、血管生成、迁移、凋亡逃避机制和细胞永生等。找到癌症发生过程中这些通路的关键标记物和对应的抗体用于检测至关重要。
为您推荐一个泛素化位点预测神器——泛素化分析工具，可以为您的蛋白的泛素化位点作出预测和评分。
细胞自噬受体图形绘图工具为你的蛋白的细胞受体结合位点作出预测和评分，识别结合到自噬通路中的蛋白是非常重要的，便于让我们理解自噬在正常生理、病理过程中的作用，如发育、细胞分化、神经退化性疾病、压力条件下、感染和癌症。
Anti-ADGRL3 / LPHN3 Antibody (C-Terminus)
Rabbit Anti Human Polyclonal Antibody
- 产品详情
- 实验流程
Application 
| IHC-P |
|---|---|
| Primary Accession | Q9HAR2 |
| Predicted | Human, Mouse, Rat, Hamster, Monkey, Chicken, Horse |
| Host | Rabbit |
| Clonality | Polyclonal |
| Calculated MW | 161812 Da |
| Concentration (mg/ml) | 1 mg/ml |
| Gene ID | 23284 |
|---|---|
| Alias Symbol | ADGRL3 |
| Other Names | ADGRL3, CIRL3, CIRL-3, Lectomedin 3, Lectomedin-3, Lph3, KIAA0768, Latrophilin 3, Latrophilin homolog 3 (cow), LPHN3, Cl3 latrotoxin receptor, Latrophilin-3, LEC3 |
| Target/Specificity | Human LPHN3. BLAST analysis of the peptide immunogen showed no homology with other human proteins. |
| Reconstitution & Storage | Immunoaffinity purified |
| Precautions | Anti-ADGRL3 / LPHN3 Antibody (C-Terminus) is for research use only and not for use in diagnostic or therapeutic procedures. |
| Name | ADGRL3 {ECO:0000303|PubMed:35418682, ECO:0000312|HGNC:HGNC:20974} |
|---|---|
| Function | Orphan adhesion G-protein coupled receptor (aGPCR), which mediates synapse specificity (PubMed:35418682). Ligand binding causes a conformation change that triggers signaling via guanine nucleotide- binding proteins (G proteins) and modulates the activity of downstream effectors (PubMed:35418682). ADGRL3 is coupled with different classes of G alpha proteins, such as G(12)/G(13), G(s), G(i) or G(q), depending on the context (PubMed:35418682). Coupling to G(12)/G(13) G proteins, which mediates the activation Rho small GTPases is the most efficient (PubMed:35418682). Following G-protein coupled receptor activation, associates with cell adhesion molecules that are expressed at the surface of adjacent cells to direct synapse specificity (PubMed:26235030). Specifically mediates the establishment of Schaffer- collateral synapses formed by CA3-region axons on CA1-region pyramidal neurons in the hippocampus (By similarity). Localizes to postsynaptic spines in excitatory synapses in the S.oriens and S.radiatum and interacts with presynaptic cell adhesion molecules FLRT3 and TENM2, promoting synapse formation (By similarity). Plays a role in the development of glutamatergic synapses in the cortex (By similarity). Important in determining the connectivity rates between the principal neurons in the cortex (By similarity). |
| Cellular Location | Cell membrane; Multi-pass membrane protein. Postsynaptic cell membrane {ECO:0000250|UniProtKB:Q80TS3}; Multi-pass membrane protein. Cell projection, axon {ECO:0000250|UniProtKB:Q80TS3}. Cell junction {ECO:0000250|UniProtKB:Q80TS3} |
Research Areas
For Research Use Only. Not For Use In Diagnostic Procedures.
Application Protocols
Provided below are standard protocols that you may find useful for product applications.
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