Anti-CHRM2 / M2 Antibody (Cytoplasmic Domain)

Rabbit Anti Human Polyclonal Antibody

Product Information
Application Applications Legend: E=ELISA WB=Western Blotting IHC=Immunohistochemistry IHC-P=Immunohistochemistry (Paraffin) IP=Immunoprecipitation IF=Immunofluorescence IC=Immunochemistry ICC=Immunocytochemistry FC=Flow Cytometry DB=Dot Blot	IHC-P
Primary Accession	P08172
Predicted	Human, Rabbit, Monkey, Sheep, Bovine
Host	Rabbit
Clonality	Polyclonal
Calculated MW	51715 Da
Concentration (mg/ml)	1 mg/ml

Additional Information
Gene ID	1129
Alias Symbol	CHRM2
Other Names	CHRM2, 7TM receptor, HM2, M2 muscarinic receptor, M2-mAChR, Muscarinic receptor M2, Muscarinic M2 receptor
Target/Specificity	Human CHRM2. BLAST analysis of the peptide immunogen showed no homology with other human proteins.
Reconstitution & Storage	Immunoaffinity purified
Precautions	Anti-CHRM2 / M2 Antibody (Cytoplasmic Domain) is for research use only and not for use in diagnostic or therapeutic procedures.

Protein Information
Name	CHRM2
Function	Muscarinic receptor for acetylcholine, a neurotransmitter found in the brain, neuromuscular junctions and the autonomic ganglia (PubMed:24256733, PubMed:3443095, PubMed:36690613). Ligand binding causes a conformation change that triggers signaling via guanine nucleotide-binding proteins (G proteins) and modulates the activity of downstream effectors, such as adenylate cyclase (PubMed:36690613). CHRM2 is coupled to G(i)/G(o) (GNAI1 or GNAO1) G proteins and mediates signaling by inhibiting adenylate cyclase activity (PubMed:36690613).
Cellular Location	Cell membrane; Multi-pass membrane protein. Postsynaptic cell membrane; Multi-pass membrane protein. Note=Phosphorylation in response to agonist binding promotes receptor internalization {ECO:0000250\|UniProtKB:P06199}