癌症的基本特征包括细胞增殖、血管生成、迁移、凋亡逃避机制和细胞永生等。找到癌症发生过程中这些通路的关键标记物和对应的抗体用于检测至关重要。
为您推荐一个泛素化位点预测神器——泛素化分析工具，可以为您的蛋白的泛素化位点作出预测和评分。
细胞自噬受体图形绘图工具为你的蛋白的细胞受体结合位点作出预测和评分，识别结合到自噬通路中的蛋白是非常重要的，便于让我们理解自噬在正常生理、病理过程中的作用，如发育、细胞分化、神经退化性疾病、压力条件下、感染和癌症。
Anti-GPR3 Antibody (N-Terminus)
Rabbit Anti Human Polyclonal Antibody
- 产品详情
- 实验流程
Application 
| IHC-P, E |
|---|---|
| Primary Accession | P46089 |
| Predicted | Human, Monkey |
| Host | Rabbit |
| Clonality | Polyclonal |
| Calculated MW | 35010 Da |
| Concentration (mg/ml) | 1 mg/ml |
| Gene ID | 2827 |
|---|---|
| Alias Symbol | GPR3 |
| Other Names | GPR3, ACCA, ACCA orphan receptor, G protein-coupled receptor 3, GPCR3, Hacca, G-protein coupled receptor 3 |
| Target/Specificity | Human GPR3. BLAST analysis of the peptide immunogen showed no homology with other human proteins, except CASKIN2 (53%), INPPL1 (47%). |
| Reconstitution & Storage | Immunoaffinity purified |
| Precautions | Anti-GPR3 Antibody (N-Terminus) is for research use only and not for use in diagnostic or therapeutic procedures. |
For Research Use Only. Not For Use In Diagnostic Procedures.
| Name | GPR3 |
|---|---|
| Synonyms | ACCA |
| Function | Constitutively active G protein-coupled receptor that maintains high cAMP levels and contributes to several processes, including meiotic arrest in oocytes and neuronal development, through activation of intracellular signaling pathways. Essential activator of thermogenic adipocytes, where it drives thermogenesis via constitutive G(s)-coupling activity in the absence of ligand (PubMed:34048700). May be activated by lipid-derived agonists such as oleoylethanolamide (OEA), oleic acid or sphingosine 1-phosphate leading to activation of the G(s)/cAMP/PKA signaling pathway (PubMed:12220620, PubMed:38376112, PubMed:38287117). Plays a potential role in modulating brain functions, including behavioral responses to stress and amyloid-beta peptide generation in neurons (By similarity). Stimulates neurite outgrowth in cerebellar granule neurons via PKA, ERK, and PI3K-mediated signaling pathways (By similarity). |
| Cellular Location | Cell membrane; Multi-pass membrane protein. |
| Tissue Location | Expressed predominantly in the central nervous system, and at low levels in the lung, kidney, testis, ovary and eye Highly expressed in regions of the brain implicated in the Alzheimer disease |
Research Areas
Application Protocols
Provided below are standard protocols that you may find useful for product applications.
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