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>   首页   >   产品   >   一抗   >   心血管   >   Anti-BOB / GPR15 Antibody (C-Terminus)   

Anti-BOB / GPR15 Antibody (C-Terminus)

Rabbit Anti Human Polyclonal Antibody

     
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Product Information
Application
  • Applications Legend:
  • E=ELISA
  • WB=Western Blotting
  • IHC=Immunohistochemistry
  • IHC-P=Immunohistochemistry (Paraffin)
  • IP=Immunoprecipitation
  • IF=Immunofluorescence
  • IC=Immunochemistry
  • ICC=Immunocytochemistry
  • FC=Flow Cytometry
  • DB=Dot Blot
IHC-P, E
Primary Accession P49685
Predicted Human
Host Rabbit
Clonality Polyclonal
Calculated MW 40787 Da
Concentration (mg/ml) 1 mg/ml
Additional Information
Gene ID 2838
Alias Symbol GPR15
Other Names GPR15, Brother of Bonzo, G protein-coupled receptor 15, G-protein coupled receptor 15, BOB, Gpr-15
Target/Specificity Human GPR15. BLAST analysis of the peptide immunogen showed no homology with other human proteins.
Reconstitution & Storage Immunoaffinity purified
PrecautionsAnti-BOB / GPR15 Antibody (C-Terminus) is for research use only and not for use in diagnostic or therapeutic procedures.
Protein Information
Name GPR15
Function G protein-coupled receptor that plays an important role in immune homeostasis (PubMed:33758080, PubMed:38918398). Acts via its natural ligand GPR15LG, a chemokine-like polypeptide strongly expressed in gastrointestinal tissues. GPR15-GPR15LG signaling axis regulates intestinal homeostasis and inflammation through the migration of immune cells (PubMed:33758080, PubMed:38918398). Controls thereby the specific homing of T-cells, particularly FOXP3+ regulatory T-cells (Tregs), to the large intestine lamina propria (By similarity). Also required for skin localization of thymus-derived dendritic epidermal T-cells (By similarity). Plays an important role in mediating cytoprotective function as well as angiogenesis of thrombomodulin (By similarity). Mechanistically, preferentially signals through the Gi/o pathway to inhibit adenylate cyclase activity and activate a phosphatidylinositol- calcium second messenger system that regulates the release of Ca(2+) ions from intracellular stores (PubMed:35510660).
Cellular Location Cell membrane; Multi-pass membrane protein
Tissue Location Highly expressed in lymphoid tissues, including macrophages and peripheral blood mononuclear cells
Research Areas

For Research Use Only. Not For Use In Diagnostic Procedures.

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