癌症的基本特征包括细胞增殖、血管生成、迁移、凋亡逃避机制和细胞永生等。找到癌症发生过程中这些通路的关键标记物和对应的抗体用于检测至关重要。
为您推荐一个泛素化位点预测神器——泛素化分析工具，可以为您的蛋白的泛素化位点作出预测和评分。
细胞自噬受体图形绘图工具为你的蛋白的细胞受体结合位点作出预测和评分，识别结合到自噬通路中的蛋白是非常重要的，便于让我们理解自噬在正常生理、病理过程中的作用，如发育、细胞分化、神经退化性疾病、压力条件下、感染和癌症。
Anti-OPRK1 / Kappa Opioid Receptor Antibody (Extracellular Domain)
Rabbit Anti Human Polyclonal Antibody
- 产品详情
- 实验流程
Application 
| IHC-P |
|---|---|
| Primary Accession | P41145 |
| Predicted | Human, Rat, Rabbit, Monkey, Horse, Dog |
| Host | Rabbit |
| Clonality | Polyclonal |
| Calculated MW | 42645 Da |
| Concentration (mg/ml) | 1 mg/ml |
| Gene ID | 4986 |
|---|---|
| Alias Symbol | OPRK1 |
| Other Names | OPRK1, Kappa-type opioid receptor, Opiate receptor, kappa-1, K-OR-1, KOR, Opioid receptor, kappa 1, OPRK, Ork1, Kappa opioid receptor, KOR-1, Opioid receptor kappa |
| Target/Specificity | Human Kappa Opioid Receptor. BLAST analysis of the peptide immunogen showed no homology with other human proteins. |
| Reconstitution & Storage | Immunoaffinity purified |
| Precautions | Anti-OPRK1 / Kappa Opioid Receptor Antibody (Extracellular Domain) is for research use only and not for use in diagnostic or therapeutic procedures. |
For Research Use Only. Not For Use In Diagnostic Procedures.
| Name | OPRK1 |
|---|---|
| Synonyms | OPRK |
| Function | G protein-coupled opioid receptor that functions as a receptor for endogenous alpha-neoendorphins and dynorphins, but has low affinity for beta-endorphins. Also functions as a receptor for various synthetic opioids and for the psychoactive diterpene salvinorin A. Ligand binding causes a conformation change that triggers signaling via guanine nucleotide-binding proteins (G proteins) and modulates the activity of down-stream effectors, such as adenylate cyclase. Signaling leads to the inhibition of adenylate cyclase activity. Inhibits neurotransmitter release by reducing calcium ion currents and increasing potassium ion conductance. Plays a role in the perception of pain. Plays a role in mediating reduced physical activity upon treatment with synthetic opioids. Plays a role in the regulation of salivation in response to synthetic opioids. May play a role in arousal and regulation of autonomic and neuroendocrine functions. |
| Cellular Location | Cell membrane; Multi-pass membrane protein |
| Tissue Location | Detected in brain and placenta. |
Research Areas
Application Protocols
Provided below are standard protocols that you may find useful for product applications.
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