癌症的基本特征包括细胞增殖、血管生成、迁移、凋亡逃避机制和细胞永生等。找到癌症发生过程中这些通路的关键标记物和对应的抗体用于检测至关重要。
为您推荐一个泛素化位点预测神器——泛素化分析工具，可以为您的蛋白的泛素化位点作出预测和评分。
细胞自噬受体图形绘图工具为你的蛋白的细胞受体结合位点作出预测和评分，识别结合到自噬通路中的蛋白是非常重要的，便于让我们理解自噬在正常生理、病理过程中的作用，如发育、细胞分化、神经退化性疾病、压力条件下、感染和癌症。
Anti-TM9SF4 Antibody (N-Terminus)
Rabbit Anti Human Polyclonal Antibody
- 产品详情
- 实验流程
Application 
| IHC-P |
|---|---|
| Primary Accession | Q92544 |
| Predicted | Human, Rabbit, Monkey, Pig, Dog |
| Host | Rabbit |
| Clonality | Polyclonal |
| Calculated MW | 74519 Da |
| Concentration (mg/ml) | 1 mg/ml |
| Gene ID | 9777 |
|---|---|
| Alias Symbol | TM9SF4 |
| Other Names | TM9SF4, DJ836N17.2, KIAA0255 |
| Target/Specificity | Human TM9SF4. BLAST analysis of the peptide immunogen showed no homology with other human proteins. |
| Reconstitution & Storage | Immunoaffinity purified |
| Precautions | Anti-TM9SF4 Antibody (N-Terminus) is for research use only and not for use in diagnostic or therapeutic procedures. |
For Research Use Only. Not For Use In Diagnostic Procedures.
| Name | TM9SF4 |
|---|---|
| Synonyms | KIAA0255, TUCAP1 {ECO:0000303|PubMed:198 |
| Function | Associates with proteins harboring glycine-rich transmembrane domains and ensures their efficient localization to the cell surface (PubMed:25999474). Regulates the assembly and activity of V-ATPase in colon cancer cells via its interaction with V-type proton ATPase subunit H (ATP6V1H) and contributes to V-ATPase-mediated pH alterations in cancer cells which play an important role in drug resistance and invasiveness of colon cancer cells (PubMed:25659576). Plays an important role in an atypical phagocytic activity of metastatic melanoma cells called cannibalism and is involved in the pH regulation of the intracellular vesicles in tumor cells (PubMed:19893578). |
| Cellular Location | Membrane; Multi-pass membrane protein. Golgi apparatus Early endosome |
| Tissue Location | Highly expressed in metastatic melanoma cells whereas it is undetectable in primary melanoma cells, healthy skin tissues and peripheral blood lymphocytes. Expressed in CD34(+) hematopoietic progenitor cells and during monocyte and granulocyte differentiation. Overexpressed in acute myeloid leukemia, in particular in those displaying granulocytic differentiation (at protein level) |
Research Areas
Application Protocols
Provided below are standard protocols that you may find useful for product applications.
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