癌症的基本特征包括细胞增殖、血管生成、迁移、凋亡逃避机制和细胞永生等。找到癌症发生过程中这些通路的关键标记物和对应的抗体用于检测至关重要。
为您推荐一个泛素化位点预测神器——泛素化分析工具，可以为您的蛋白的泛素化位点作出预测和评分。
细胞自噬受体图形绘图工具为你的蛋白的细胞受体结合位点作出预测和评分，识别结合到自噬通路中的蛋白是非常重要的，便于让我们理解自噬在正常生理、病理过程中的作用，如发育、细胞分化、神经退化性疾病、压力条件下、感染和癌症。
Anti-TAOK2 / TAO2 Antibody (clone 2E2)
Mouse Anti Human Monoclonal Antibody
- 产品详情
- 实验流程
Application 
| WB, IHC-P, E |
|---|---|
| Primary Accession | Q9UL54 |
| Predicted | Human |
| Host | Mouse |
| Clonality | Monoclonal |
| Isotype | IgG2a,k |
| Clone Names | 2E2 |
| Calculated MW | 138251 Da |
| Concentration (mg/ml) | 0.5 mg/ml |
| Gene ID | 9344 |
|---|---|
| Alias Symbol | TAOK2 |
| Other Names | TAOK2, Kinase from chicken homolog C, HKFC-C, PSK, PSK-1, PSK1-BETA, TAO1, TAO kinase 2, TAO2, PSK1, KIAA0881, MAP3K17 |
| Reconstitution & Storage | Protein A purified |
| Precautions | Anti-TAOK2 / TAO2 Antibody (clone 2E2) is for research use only and not for use in diagnostic or therapeutic procedures. |
For Research Use Only. Not For Use In Diagnostic Procedures.
| Name | TAOK2 |
|---|---|
| Synonyms | KIAA0881, MAP3K17, PSK, PSK1 |
| Function | Serine/threonine-protein kinase involved in different processes such as membrane blebbing and apoptotic bodies formation DNA damage response and MAPK14/p38 MAPK stress-activated MAPK cascade. Phosphorylates itself, MBP, activated MAPK8, MAP2K3, MAP2K6 and tubulins. Activates the MAPK14/p38 MAPK signaling pathway through the specific activation and phosphorylation of the upstream MAP2K3 and MAP2K6 kinases. In response to DNA damage, involved in the G2/M transition DNA damage checkpoint by activating the p38/MAPK14 stress- activated MAPK cascade, probably by mediating phosphorylation of upstream MAP2K3 and MAP2K6 kinases. Isoform 1, but not isoform 2, plays a role in apoptotic morphological changes, including cell contraction, membrane blebbing and apoptotic bodies formation. This function, which requires the activation of MAPK8/JNK and nuclear localization of C- terminally truncated isoform 1, may be linked to the mitochondrial CASP9-associated death pathway. Isoform 1 binds to microtubules and affects their organization and stability independently of its kinase activity. Prevents MAP3K7-mediated activation of CHUK, and thus NF- kappa-B activation, but not that of MAPK8/JNK. May play a role in the osmotic stress-MAPK8 pathway. Isoform 2, but not isoform 1, is required for PCDH8 endocytosis. Following homophilic interactions between PCDH8 extracellular domains, isoform 2 phosphorylates and activates MAPK14/p38 MAPK which in turn phosphorylates isoform 2. This process leads to PCDH8 endocytosis and CDH2 cointernalization. Both isoforms are involved in MAPK14 phosphorylation. |
| Cellular Location | Cytoplasmic vesicle membrane; Multi-pass membrane protein. Cytoplasm, cytoskeleton Nucleus. Note=Catalytically active full-length phosphorylated isoform 1 localizes to microtubules in the cytoplasm predominantly on microtubule cables positioned around the nucleus. A C-terminally truncated form of isoform 1 is present in the nucleus; isoform 2 and kinase-defective, as well as full-length isoform 1 are excluded from the nucleus |
| Tissue Location | Ubiquitously expressed, with a higher level of expression in testis and brain. |
Research Areas
Application Protocols
Provided below are standard protocols that you may find useful for product applications.
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