Anti-SLC5A6 / SMVT Antibody (N-Terminus)

Rabbit Anti Human Polyclonal Antibody

Product Information
Application Applications Legend: E=ELISA WB=Western Blotting IHC=Immunohistochemistry IHC-P=Immunohistochemistry (Paraffin) IP=Immunoprecipitation IF=Immunofluorescence IC=Immunochemistry ICC=Immunocytochemistry FC=Flow Cytometry DB=Dot Blot	IHC-P
Primary Accession	Q9Y289
Predicted	Human, Rat
Host	Rabbit
Clonality	Polyclonal
Calculated MW	68642 Da
Concentration (mg/ml)	1 mg/ml

Additional Information
Gene ID	8884
Alias Symbol	SLC5A6
Other Names	SLC5A6, SMVT
Target/Specificity	Human SLC5A6. BLAST analysis of the peptide immunogen showed no homology with other human proteins.
Reconstitution & Storage	Immunoaffinity purified
Precautions	Anti-SLC5A6 / SMVT Antibody (N-Terminus) is for research use only and not for use in diagnostic or therapeutic procedures.

Protein Information
Name	SLC5A6 (HGNC:11041)
Synonyms	SMVT
Function	Sodium-dependent multivitamin transporter that mediates the electrogenic transport of pantothenate, biotin, lipoate and iodide (PubMed:10329687, PubMed:15561972, PubMed:19211916, PubMed:20980265, PubMed:21570947, PubMed:22015582, PubMed:25809983, PubMed:25971966, PubMed:27904971, PubMed:28052864, PubMed:31754459). Functions as a Na(+)-coupled substrate symporter where the stoichiometry of Na(+):substrate is 2:1, creating an electrochemical Na(+) gradient used as driving force for substrate uptake (PubMed:10329687, PubMed:20980265). Required for biotin and pantothenate uptake in the intestine across the brush border membrane (PubMed:19211916). Plays a role in the maintenance of intestinal mucosa integrity, by providing the gut mucosa with biotin (By similarity). Contributes to the luminal uptake of biotin and pantothenate into the brain across the blood-brain barrier (PubMed:25809983).
Cellular Location	Cell membrane; Multi-pass membrane protein. Apical cell membrane; Multi-pass membrane protein. Note=Preferentially localized at the luminal membrane of brain capillary endothelium (PubMed:25809983). Localized to the brush border/apical membrane of intestine and renal polarized cells (PubMed:19211916).
Tissue Location	Expressed in microvessels of the brain (at protein level) (PubMed:25809983). Expressed in heart, brain, placenta, lung, liver, skeletal muscle, kidney, and pancreas (PubMed:10329687)