Anti-GPR171 Antibody (Extracellular Domain)

Rabbit Anti Human Polyclonal Antibody

Product Information
Application Applications Legend: E=ELISA WB=Western Blotting IHC=Immunohistochemistry IHC-P=Immunohistochemistry (Paraffin) IP=Immunoprecipitation IF=Immunofluorescence IC=Immunochemistry ICC=Immunocytochemistry FC=Flow Cytometry DB=Dot Blot	IHC-P
Primary Accession	O14626
Predicted	Human, Rabbit, Monkey, Bovine
Host	Rabbit
Clonality	Polyclonal
Calculated MW	36754 Da
Concentration (mg/ml)	1 mg/ml

Additional Information
Gene ID	29909
Alias Symbol	GPR171
Other Names	GPR171, H963, G protein-coupled receptor 171
Target/Specificity	Human GPR171. BLAST analysis of the peptide immunogen showed no homology with other human proteins.
Reconstitution & Storage	Immunoaffinity purified
Precautions	Anti-GPR171 Antibody (Extracellular Domain) is for research use only and not for use in diagnostic or therapeutic procedures.

Protein Information
Name	GPR171 (HGNC:30057)
Synonyms	H963
Function	G-protein coupled receptor for Big LEN, a 16-amino acid neuropeptide produced from the precursor protein, proSAAS (encoded by PCSK1N). Acts through a G(i)-alpha-mediated pathway in response to Big LEN. Big LEN-GPR171 system plays an important role in regulating feeding and metabolism. Also plays a role in modulating fear and anxiety-like behaviors in the basolateral amygdala. Big LEN-GPR171 modulates the mu-type opioid receptor signaling and antinociception (By similarity). Acts as a negative regulator T cell function (PubMed:34615877).
Cellular Location	Cell membrane {ECO:0000250\|UniProtKB:Q8BG55}; Multi-pass membrane protein. Note=Colocalized with GPR83 in the paraventricular nucleus. {ECO:0000250\|UniProtKB:Q8BG55}
Tissue Location	Expressed in both T-cell subsets and natural killer cells, while it is undetectable in B cells or CD14(+) monocytes Expressed in peripheral blood mononuclear cells (PBMC) and Jurkat cells (at protein level).