癌症的基本特征包括细胞增殖、血管生成、迁移、凋亡逃避机制和细胞永生等。找到癌症发生过程中这些通路的关键标记物和对应的抗体用于检测至关重要。
为您推荐一个泛素化位点预测神器——泛素化分析工具，可以为您的蛋白的泛素化位点作出预测和评分。
细胞自噬受体图形绘图工具为你的蛋白的细胞受体结合位点作出预测和评分，识别结合到自噬通路中的蛋白是非常重要的，便于让我们理解自噬在正常生理、病理过程中的作用，如发育、细胞分化、神经退化性疾病、压力条件下、感染和癌症。
Anti-PTPRN / IA-2 Antibody (clone 8E3)
Mouse Anti Human Monoclonal Antibody
- 产品详情
- 实验流程
Application 
| WB, IHC-P, E |
|---|---|
| Primary Accession | Q16849 |
| Predicted | Human |
| Host | Mouse |
| Clonality | Monoclonal |
| Isotype | IgG2a,k |
| Clone Names | 8E3 |
| Calculated MW | 105848 Da |
| Concentration (mg/ml) | 0.5 mg/ml |
| Gene ID | 5798 |
|---|---|
| Alias Symbol | PTPRN |
| Other Names | PTPRN, ICA512, IA2, ICA 512, Islet antigen 2, Islet cell antigen 2, Islet cell autoantigen 3, IA-2, Ia-2 antigen, ICA3, PTP-NP-2, PTP IA-2, R-PTP-N, IA-2/PTP, Islet cell antigen 512 |
| Target/Specificity | Human PTPRN |
| Reconstitution & Storage | Protein A purified |
| Precautions | Anti-PTPRN / IA-2 Antibody (clone 8E3) is for research use only and not for use in diagnostic or therapeutic procedures. |
For Research Use Only. Not For Use In Diagnostic Procedures.
| Name | PTPRN |
|---|---|
| Synonyms | ICA3, ICA512 |
| Function | Plays a role in vesicle-mediated secretory processes (PubMed:24843546). Required for normal accumulation of secretory vesicles in hippocampus, pituitary and pancreatic islets (By similarity). Required for the accumulation of normal levels of insulin- containing vesicles and preventing their degradation (PubMed:24843546). Plays a role in insulin secretion in response to glucose stimuli (PubMed:24843546). Required for normal accumulation of the neurotransmitters norepinephrine, dopamine and serotonin in the brain (By similarity). In females, but not in males, required for normal accumulation and secretion of pituitary hormones, such as luteinizing hormone (LH) and follicle-stimulating hormone (FSH) (By similarity). Required to maintain normal levels of renin expression and renin release (By similarity). Seems to lack intrinsic enzyme activity (By similarity). May regulate catalytic active protein-tyrosine phosphatases such as PTPRA through dimerization (By similarity). |
| Cellular Location | Membrane {ECO:0000250|UniProtKB:Q63259}; Single- pass type I membrane protein {ECO:0000250|UniProtKB:Q63259} Cytoplasmic vesicle, secretory vesicle membrane; Single-pass type I membrane protein. Perikaryon {ECO:0000250|UniProtKB:Q63259}. Cell projection, axon {ECO:0000250|UniProtKB:Q63259}. Synapse {ECO:0000250|UniProtKB:Q63259}. Cell membrane; Single-pass type I membrane protein {ECO:0000250|UniProtKB:Q63259}. Endosome {ECO:0000250|UniProtKB:Q63259}. Note=Detected on neuronal secretory vesicles, but not on synaptic vesicles. Colocalizes with insulin- containing secretory granules (PubMed:25561468). Primarily detected on secretory vesicle membranes. Transiently found at the cell membrane, when secretory vesicles fuse with the cell membrane to release their cargo. Is then endocytosed and recycled to secretory vesicles via the Golgi apparatus membranes. {ECO:0000250|UniProtKB:Q63259, ECO:0000269|PubMed:25561468} [ICA512-cleaved cytosolic fragment]: Nucleus |
| Tissue Location | Expression is restricted to neuroendocrine cells. Found in pancreas, brain and pituitary. |
Research Areas
Application Protocols
Provided below are standard protocols that you may find useful for product applications.
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