癌症的基本特征包括细胞增殖、血管生成、迁移、凋亡逃避机制和细胞永生等。找到癌症发生过程中这些通路的关键标记物和对应的抗体用于检测至关重要。
为您推荐一个泛素化位点预测神器——泛素化分析工具，可以为您的蛋白的泛素化位点作出预测和评分。
细胞自噬受体图形绘图工具为你的蛋白的细胞受体结合位点作出预测和评分，识别结合到自噬通路中的蛋白是非常重要的，便于让我们理解自噬在正常生理、病理过程中的作用，如发育、细胞分化、神经退化性疾病、压力条件下、感染和癌症。
Anti-Carom / FCHSD2 Antibody
Rabbit Anti Human Polyclonal Antibody
- 产品详情
- 实验流程
Application 
| IHC-P |
|---|---|
| Primary Accession | O94868 |
| Predicted | Human |
| Host | Rabbit |
| Clonality | Polyclonal |
| Calculated MW | 84276 Da |
| Concentration (mg/ml) | 1 mg/ml |
| Gene ID | 9873 |
|---|---|
| Alias Symbol | FCHSD2 |
| Other Names | FCHSD2, Carom, FCH and double SH3 domains 2, NWK, KIAA0769, Nervous wreck homolog, SH3 multiple domains 3, SH3 multiple domains protein 3, SH3MD3 |
| Reconstitution & Storage | Immunoaffinity purified |
| Precautions | Anti-Carom / FCHSD2 Antibody is for research use only and not for use in diagnostic or therapeutic procedures. |
| Name | FCHSD2 |
|---|---|
| Synonyms | KIAA0769, SH3MD3 |
| Function | Adapter protein that plays a role in endocytosis via clathrin-coated pits. Contributes to the internalization of cell surface receptors, such as integrin ITGB1 and transferrin receptor (PubMed:29887380). Promotes endocytosis of EGFR in cancer cells, and thereby contributes to the down-regulation of EGFR signaling (PubMed:30249660). Recruited to clathrin-coated pits during a mid-to- late stage of assembly, where it is required for normal progress from U-shaped intermediate stage pits to terminal, omega-shaped pits (PubMed:29887380). Binds to membranes enriched in phosphatidylinositol 3,4-bisphosphate or phosphatidylinositol 3,4,5-trisphosphate (PubMed:29887380). When bound to membranes, promotes actin polymerization via its interaction with WAS and/or WASL which leads to the activation of the Arp2/3 complex. Does not promote actin polymerisation in the absence of membranes (PubMed:29887380). |
| Cellular Location | Cytoplasm {ECO:0000250|UniProtKB:Q3USJ8}. Cell junction. Membrane, clathrin-coated pit. Cell membrane; Peripheral membrane protein; Cytoplasmic side. Cell projection, stereocilium {ECO:0000250|UniProtKB:Q3USJ8}. Note=Partially localized at clathrin-coated pits at the cell membrane (PubMed:30249660). Detected at the cell membrane at sites around clathrin-coated pits, very close to the clathrin-coated pits but not an intrinsic part of the clathrin-coated pits (PubMed:29887380) Colocalizes at cell-cell contacts with CDH1, but is not detected at tight junctions (PubMed:14627983). |
| Tissue Location | Liver, brain, heart, placenta, skeletal muscle, pancreas, lung and kidney. |
Research Areas
For Research Use Only. Not For Use In Diagnostic Procedures.
Application Protocols
Provided below are standard protocols that you may find useful for product applications.
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