癌症的基本特征包括细胞增殖、血管生成、迁移、凋亡逃避机制和细胞永生等。找到癌症发生过程中这些通路的关键标记物和对应的抗体用于检测至关重要。
为您推荐一个泛素化位点预测神器——泛素化分析工具，可以为您的蛋白的泛素化位点作出预测和评分。
细胞自噬受体图形绘图工具为你的蛋白的细胞受体结合位点作出预测和评分，识别结合到自噬通路中的蛋白是非常重要的，便于让我们理解自噬在正常生理、病理过程中的作用，如发育、细胞分化、神经退化性疾病、压力条件下、感染和癌症。
Anti-PPP2R4 Antibody (aa347-358)
Goat Anti Human Polyclonal Antibody
- 产品详情
- 实验流程
Application 
| WB, IHC-P, E |
|---|---|
| Primary Accession | Q15257 |
| Predicted | Human, Mouse, Rat, Rabbit, Hamster, Monkey |
| Host | Goat |
| Clonality | Polyclonal |
| Calculated MW | 40668 Da |
| Concentration (mg/ml) | 0.5 mg/ml |
| Gene ID | 5524 |
|---|---|
| Alias Symbol | PPP2R4 |
| Other Names | PPP2R4, PP2A phosphatase activator, PP2A subunit B isoform PR53, PTPA, PP2A, PP2A, subunit B, PR53 isoform, PR53 |
| Target/Specificity | Human PPP2R4. This antibody is expected to recognize all reported isoforms (NP_821068.1; NP_066954.2; NP_821070.1). Reported variants NP_066954.2 and NP_821067.1 represent identical protein. |
| Reconstitution & Storage | Immunoaffinity purified |
| Precautions | Anti-PPP2R4 Antibody (aa347-358) is for research use only and not for use in diagnostic or therapeutic procedures. |
For Research Use Only. Not For Use In Diagnostic Procedures.
| Name | PTPA (HGNC:9308) |
|---|---|
| Synonyms | PPP2R4 |
| Function | PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides (By similarity). Acts as a regulatory subunit for serine/threonine-protein phosphatase 2A (PP2A) (PubMed:16916641, PubMed:36073231). Modulates PP2A activity or substrate specificity, probably by inducing a conformational change in the catalytic subunit, a proposed direct target of the PPIase (PubMed:16916641). Can reactivate inactive phosphatase PP2A-phosphatase methylesterase complexes (PP2A(i)) in presence of ATP and Mg(2+) (By similarity). Reversibly stimulates the variable phosphotyrosyl phosphatase activity of PP2A core heterodimer PP2A(D) in presence of ATP and Mg(2+) (in vitro) (PubMed:16916641). The phosphotyrosyl phosphatase activity is dependent of an ATPase activity of the PP2A(D):PPP2R4 complex (PubMed:16916641). Is involved in apoptosis; the function appears to be independent from PP2A (PubMed:17333320). |
| Cellular Location | Cytoplasm. Nucleus |
| Tissue Location | Widely expressed. |
Research Areas
Application Protocols
Provided below are standard protocols that you may find useful for product applications.
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Discontinued
Cat# ALS17812
Size:
50 µg
Price:
¥ 4,380.00
替代产品:
