癌症的基本特征包括细胞增殖、血管生成、迁移、凋亡逃避机制和细胞永生等。找到癌症发生过程中这些通路的关键标记物和对应的抗体用于检测至关重要。
为您推荐一个泛素化位点预测神器——泛素化分析工具，可以为您的蛋白的泛素化位点作出预测和评分。
细胞自噬受体图形绘图工具为你的蛋白的细胞受体结合位点作出预测和评分，识别结合到自噬通路中的蛋白是非常重要的，便于让我们理解自噬在正常生理、病理过程中的作用，如发育、细胞分化、神经退化性疾病、压力条件下、感染和癌症。
Anti-MPS1 / TTK Antibody (clone 3G7)
Mouse Anti Human Monoclonal Antibody
- 产品详情
- 实验流程
Application 
| WB, IHC-P, E |
|---|---|
| Primary Accession | P33981 |
| Predicted | Human |
| Host | Mouse |
| Clonality | Monoclonal |
| Isotype | IgG2a,k |
| Clone Names | 3G7 |
| Calculated MW | 97072 Da |
| Concentration (mg/ml) | 0.47 mg/ml |
| Gene ID | 7272 |
|---|---|
| Alias Symbol | TTK |
| Other Names | TTK, Cancer/testis antigen 96, ESK, Esk1, MPS1, MPS1L1, Protein kinase esk, PYT, TTK protein kinase, CT96, Monopolar spindle 1-like 1 |
| Target/Specificity | Human MPS1 / TTK |
| Reconstitution & Storage | Protein A purified |
| Precautions | Anti-MPS1 / TTK Antibody (clone 3G7) is for research use only and not for use in diagnostic or therapeutic procedures. |
For Research Use Only. Not For Use In Diagnostic Procedures.
| Name | TTK |
|---|---|
| Synonyms | MPS1, MPS1L1 |
| Function | Involved in mitotic spindle assembly checkpoint signaling, a process that delays anaphase until chromosomes are bioriented on the spindle, and in the repair of incorrect mitotic kinetochore-spindle microtubule attachments (PubMed:18243099, PubMed:28441529, PubMed:29162720). Phosphorylates MAD1L1 to promote the mitotic spindle assembly checkpoint (PubMed:18243099, PubMed:29162720). Phosphorylates CDCA8/Borealin leading to enhanced AURKB activity at the kinetochore (PubMed:18243099). Phosphorylates SKA3 at 'Ser-34' leading to dissociation of the SKA complex from microtubules and destabilization of microtubule-kinetochore attachments (PubMed:28441529). Phosphorylates KNL1, KNTC1 and autophosphorylates (PubMed:28441529). Phosphorylates MCRS1 which enhances recruitment of KIF2A to the minus end of spindle microtubules and promotes chromosome alignment (PubMed:30785839). |
| Tissue Location | Present in rapidly proliferating cell lines. |
Research Areas
Application Protocols
Provided below are standard protocols that you may find useful for product applications.
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