癌症的基本特征包括细胞增殖、血管生成、迁移、凋亡逃避机制和细胞永生等。找到癌症发生过程中这些通路的关键标记物和对应的抗体用于检测至关重要。
为您推荐一个泛素化位点预测神器——泛素化分析工具，可以为您的蛋白的泛素化位点作出预测和评分。
细胞自噬受体图形绘图工具为你的蛋白的细胞受体结合位点作出预测和评分，识别结合到自噬通路中的蛋白是非常重要的，便于让我们理解自噬在正常生理、病理过程中的作用，如发育、细胞分化、神经退化性疾病、压力条件下、感染和癌症。
Anti-CBR / CBR1 Antibody (aa181-230)
Rabbit Anti Human Polyclonal Antibody
- 产品详情
- 实验流程
Application 
| WB, IHC-P, E |
|---|---|
| Primary Accession | P16152 |
| Predicted | Human |
| Host | Rabbit |
| Clonality | Polyclonal |
| Isotype | IgG |
| Calculated MW | 30375 Da |
| Gene ID | 873 |
|---|---|
| Alias Symbol | CBR1 |
| Other Names | CBR1, Carbonyl reductase 1, Carbonyl reductase (NADPH) 1, HCBR1, Prostaglandin 9-ketoreductase, SDR21C1, Carbonyl reductase [NADPH] 1, CBR, CRN, Prostaglandin-E(2) 9-reductase |
| Target/Specificity | CBR1 Antibody detects endogenous levels of total CBR1 protein. |
| Reconstitution & Storage | Immunoaffinity purified |
| Precautions | Anti-CBR / CBR1 Antibody (aa181-230) is for research use only and not for use in diagnostic or therapeutic procedures. |
For Research Use Only. Not For Use In Diagnostic Procedures.
| Name | CBR1 (HGNC:1548) |
|---|---|
| Synonyms | CBR, CRN, SDR21C1 |
| Function | NADPH-dependent reductase with broad substrate specificity. Catalyzes the reduction of a wide variety of carbonyl compounds including quinones, prostaglandins, menadione, plus various xenobiotics. Catalyzes the reduction of the antitumor anthracyclines doxorubicin and daunorubicin to the cardiotoxic compounds doxorubicinol and daunorubicinol (PubMed:15799708, PubMed:17344335, PubMed:17912391, PubMed:18449627, PubMed:18826943, PubMed:1921984, PubMed:7005231). Can convert prostaglandin E to prostaglandin F2-alpha (By similarity). Can bind glutathione, which explains its higher affinity for glutathione- conjugated substrates. Catalyzes the reduction of S-nitrosoglutathione (PubMed:17344335, PubMed:18826943). In addition, participates in the glucocorticoid metabolism by catalyzing the NADPH-dependent cortisol/corticosterone into 20beta-dihydrocortisol (20b-DHF) or 20beta-corticosterone (20b-DHB), which are weak agonists of NR3C1 and NR3C2 in adipose tissue (PubMed:28878267). |
| Cellular Location | Cytoplasm. |
| Tissue Location | Expressed in kidney (at protein level). |
Research Areas
Application Protocols
Provided below are standard protocols that you may find useful for product applications.
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Discontinued
Cat# ALS17955
Size:
100 µl
Price:
¥ 4,923.00
替代产品:
