癌症的基本特征包括细胞增殖、血管生成、迁移、凋亡逃避机制和细胞永生等。找到癌症发生过程中这些通路的关键标记物和对应的抗体用于检测至关重要。
为您推荐一个泛素化位点预测神器——泛素化分析工具，可以为您的蛋白的泛素化位点作出预测和评分。
细胞自噬受体图形绘图工具为你的蛋白的细胞受体结合位点作出预测和评分，识别结合到自噬通路中的蛋白是非常重要的，便于让我们理解自噬在正常生理、病理过程中的作用，如发育、细胞分化、神经退化性疾病、压力条件下、感染和癌症。
Anti-DRD5 / Dopamine Receptor D5 Antibody
Rabbit Anti Human Polyclonal Antibody
- 产品详情
- 实验流程
Application 
| WB, IHC-P |
|---|---|
| Primary Accession | P21918 |
| Predicted | Human, Mouse, Rat |
| Host | Rabbit |
| Clonality | Polyclonal |
| Calculated MW | 52951 Da |
| Concentration (mg/ml) | 1 mg/ml |
| Gene ID | 1816 |
|---|---|
| Alias Symbol | DRD5 |
| Other Names | DRD5, D(5) dopamine receptor, D1beta dopamine receptor, D5 dopamine receptor, Dopamine 5 receptor, Dopamine receptor D5, DRD1B, D(1B) dopamine receptor, D1b dopamine receptor, D1b receptor, DBDR, Dopamine receptor 5, DRD1L2, Hd5dr, Dopamine d1b recep ... |
| Target/Specificity | Human DRD5 / Dopamine Receptor D5 |
| Reconstitution & Storage | Immunoaffinity purified |
| Precautions | Anti-DRD5 / Dopamine Receptor D5 Antibody is for research use only and not for use in diagnostic or therapeutic procedures. |
For Research Use Only. Not For Use In Diagnostic Procedures.
| Name | DRD5 {ECO:0000303|PubMed:11781417, ECO:0000312|HGNC:HGNC:3026} |
|---|---|
| Function | G protein-coupled receptor for dopamine, a catecholamine neurotransmitter hormone that functions as the brain's 'reward chemical', driving motivation, reinforcement learning and pleasure (PubMed:11500503, PubMed:1826762, PubMed:1834671, PubMed:37221270). Dopamine binding causes a conformation change that triggers signaling via guanine nucleotide-binding proteins (G proteins) and modulates the activity of downstream effectors, such as adenylate cyclase (PubMed:11500503, PubMed:1826762, PubMed:1834671, PubMed:37221270). Dopamine receptors can be classified in two categories: (1) DRD5 (together with DRD1) is a D1-type receptor and is coupled to G(s) G proteins, mediating activation of adenylate cyclase activity, while D2- type receptors (DRD2, DRD3 and DRD4) are coupled to G(i)/G(o) G proteins and promote inhibition of adenylate cyclase activity (PubMed:11500503, PubMed:1826762, PubMed:1834671, PubMed:37221270). D1- and D2-type dopamine receptors have antagonistic effects, particularly in the brain's striatum, where they govern voluntary movement and reward: D1-type receptors generally stimulate neural activity and promotes action, while D2-type receptors tend to inhibit neural activity and suppress movement (PubMed:11500503, PubMed:1826762, PubMed:1834671, PubMed:37221270). DRD5 acts as a key regulator of blood pressure: negatively regulates the renin-angiotensin system (RAS), thereby reducing renal sodium absorption by the kidney (By similarity). |
| Cellular Location | Cell membrane; Multi-pass membrane protein |
| Tissue Location | Neuron-specific, localized primarily within limbic regions of the brain. |
Research Areas
Application Protocols
Provided below are standard protocols that you may find useful for product applications.
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