Anti-HNRNPC / HNRNP C Antibody (aa222-271)

Rabbit Anti Human Polyclonal Antibody

Product Information
Application Applications Legend: E=ELISA WB=Western Blotting IHC=Immunohistochemistry IHC-P=Immunohistochemistry (Paraffin) IP=Immunoprecipitation IF=Immunofluorescence IC=Immunochemistry ICC=Immunocytochemistry FC=Flow Cytometry DB=Dot Blot	WB, IHC-P, E
Primary Accession	P07910
Predicted	Human, Mouse, Rat
Host	Rabbit
Clonality	Polyclonal
Isotype	IgG
Calculated MW	33670 Da

Additional Information
Gene ID	3183
Alias Symbol	HNRNPC
Other Names	HNRNPC, HNRPC, HnRNP C1/C2, HNRNP
Target/Specificity	HnRNP C1/C2 antibody detects endogenous levels of hnRNP C1/C2.
Reconstitution & Storage	Immunoaffinity purified
Precautions	Anti-HNRNPC / HNRNP C Antibody (aa222-271) is for research use only and not for use in diagnostic or therapeutic procedures.

Protein Information
Name	HNRNPC
Synonyms	HNRPC
Function	Binds pre-mRNA and nucleates the assembly of 40S hnRNP particles (PubMed:8264621). Interacts with poly-U tracts in the 3'-UTR or 5'-UTR of mRNA and modulates the stability and the level of translation of bound mRNA molecules (PubMed:12509468, PubMed:16010978, PubMed:7567451, PubMed:8264621). Single HNRNPC tetramers bind 230-240 nucleotides. Trimers of HNRNPC tetramers bind 700 nucleotides (PubMed:8264621). May play a role in the early steps of spliceosome assembly and pre-mRNA splicing. N6-methyladenosine (m6A) has been shown to alter the local structure in mRNAs and long non-coding RNAs (lncRNAs) via a mechanism named 'm(6)A-switch', facilitating binding of HNRNPC, leading to regulation of mRNA splicing (PubMed:25719671).
Cellular Location	Nucleus. Note=Component of ribonucleosomes