Anti-LIPA / Lysosomal Acid Lipase Antibody (clone 1F9)

Mouse Anti Human Monoclonal Antibody

Product Information
Application Applications Legend: E=ELISA WB=Western Blotting IHC=Immunohistochemistry IHC-P=Immunohistochemistry (Paraffin) IP=Immunoprecipitation IF=Immunofluorescence IC=Immunochemistry ICC=Immunocytochemistry FC=Flow Cytometry DB=Dot Blot	WB, IHC-P, E, IP
Primary Accession	P38571
Predicted	Human
Host	Mouse
Clonality	Monoclonal
Isotype	IgG2b,k
Clone Names	1F9
Calculated MW	45419 Da
Concentration (mg/ml)	1 mg/ml

Additional Information
Gene ID	3988
Alias Symbol	LIPA
Other Names	LIPA, Cholesterol ester hydrolase, Cholesteryl esterase, LAL, Lysosomal acid lipase, Lipase A, Sterol esterase, CESD
Target/Specificity	Human LIPA / Lysosomal Acid Lipase
Reconstitution & Storage	Protein A purified
Precautions	Anti-LIPA / Lysosomal Acid Lipase Antibody (clone 1F9) is for research use only and not for use in diagnostic or therapeutic procedures.

Protein Information
Name	LIPA
Function	Catalyzes the deacylation of cholesteryl ester core lipids of endocytosed low density lipoproteins to generate free fatty acids and cholesterol (PubMed:15269241, PubMed:1718995, PubMed:7204383, PubMed:8112342, PubMed:9633819). Hydrolyzes triglycerides (1,2,3- triacylglycerol) and diglycerides (such as 1,2-diacylglycerol and 1,3- diacylglycerol) with preference for the acyl moieties at the sn-1 or sn-3 positions (PubMed:7204383, PubMed:8112342).
Cellular Location	Lysosome {ECO:0000250\|UniProtKB:Q64194}.
Tissue Location	Most abundantly expressed in brain, lung, kidney and mammary gland, a moderate expression seen in placenta and expressed at low levels in the liver and heart.