癌症的基本特征包括细胞增殖、血管生成、迁移、凋亡逃避机制和细胞永生等。找到癌症发生过程中这些通路的关键标记物和对应的抗体用于检测至关重要。
为您推荐一个泛素化位点预测神器——泛素化分析工具，可以为您的蛋白的泛素化位点作出预测和评分。
细胞自噬受体图形绘图工具为你的蛋白的细胞受体结合位点作出预测和评分，识别结合到自噬通路中的蛋白是非常重要的，便于让我们理解自噬在正常生理、病理过程中的作用，如发育、细胞分化、神经退化性疾病、压力条件下、感染和癌症。
Anti-DBP5 / SON Antibody (aa1413-1628)
Rabbit Anti Human Polyclonal Antibody
- 产品详情
- 实验流程
Application 
| IHC-P, IF, ICC |
|---|---|
| Primary Accession | P18583 |
| Predicted | Human |
| Host | Rabbit |
| Clonality | Polyclonal |
| Isotype | IgG |
| Calculated MW | 263830 Da |
| Concentration (mg/ml) | 1 mg/ml |
| Gene ID | 6651 |
|---|---|
| Alias Symbol | SON |
| Other Names | SON, C21orf50, DBP5, DBP-5, KIAA1019, NREBP, Protein SON, Protein DBP-5, SON DNA binding protein, NRE-binding protein, SON3, BASS1 |
| Target/Specificity | Human DBP5 / SON. |
| Reconstitution & Storage | Immunoaffinity purified |
| Precautions | Anti-DBP5 / SON Antibody (aa1413-1628) is for research use only and not for use in diagnostic or therapeutic procedures. |
| Name | SON |
|---|---|
| Synonyms | C21orf50, DBP5, KIAA1019, NREBP |
| Function | RNA-binding protein that acts as a mRNA splicing cofactor by promoting efficient splicing of transcripts that possess weak splice sites. Specifically promotes splicing of many cell-cycle and DNA-repair transcripts that possess weak splice sites, such as TUBG1, KATNB1, TUBGCP2, AURKB, PCNT, AKT1, RAD23A, and FANCG. Probably acts by facilitating the interaction between Serine/arginine-rich proteins such as SRSF2 and the RNA polymerase II. Also binds to DNA; binds to the consensus DNA sequence: 5'-GA[GT]AN[CG][AG]CC-3'. May indirectly repress hepatitis B virus (HBV) core promoter activity and transcription of HBV genes and production of HBV virions. Essential for correct RNA splicing of multiple genes critical for brain development, neuronal migration and metabolism, including TUBG1, FLNA, PNKP, WDR62, PSMD3, PCK2, PFKL, IDH2, and ACY1 (PubMed:27545680). |
| Cellular Location | Nucleus speckle Note=Colocalizes with the pre-mRNA splicing factor SRSF2 |
| Tissue Location | Widely expressed, with the higher expression seen in leukocyte and heart |
Research Areas
For Research Use Only. Not For Use In Diagnostic Procedures.
Application Protocols
Provided below are standard protocols that you may find useful for product applications.
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