癌症的基本特征包括细胞增殖、血管生成、迁移、凋亡逃避机制和细胞永生等。找到癌症发生过程中这些通路的关键标记物和对应的抗体用于检测至关重要。
为您推荐一个泛素化位点预测神器——泛素化分析工具，可以为您的蛋白的泛素化位点作出预测和评分。
细胞自噬受体图形绘图工具为你的蛋白的细胞受体结合位点作出预测和评分，识别结合到自噬通路中的蛋白是非常重要的，便于让我们理解自噬在正常生理、病理过程中的作用，如发育、细胞分化、神经退化性疾病、压力条件下、感染和癌症。
Anti-Nectin-1 / PVRL1 Antibody
Rabbit Anti Human Polyclonal Antibody
- 产品详情
- 实验流程
Application 
| WB, IHC-P |
|---|---|
| Primary Accession | Q15223 |
| Predicted | Human, Mouse, Rat |
| Host | Rabbit |
| Clonality | Polyclonal |
| Isotype | IgG |
| Calculated MW | 57158 Da |
| Gene ID | 5818 |
|---|---|
| Alias Symbol | PVRL1 |
| Other Names | PVRL1, CD111 antigen, CLPED1, CD111, Herpesvirus entry mediator C, Herpes virus entry mediator C, Herpesvirus Ig-like receptor, Nectin 1, OFC7, Poliovirus receptor-like 1, PRR, Nectin-1, PRR1, PVRR, PVRR1, SK-12, ED4, HIgR, HVEC |
| Target/Specificity | Human Nectin-1 / PVRL1 |
| Reconstitution & Storage | Affinity purified |
| Precautions | Anti-Nectin-1 / PVRL1 Antibody is for research use only and not for use in diagnostic or therapeutic procedures. |
For Research Use Only. Not For Use In Diagnostic Procedures.
| Name | NECTIN1 {ECO:0000303|PubMed:11356977, ECO:0000312|HGNC:HGNC:9706} |
|---|---|
| Function | Cell adhesion molecule that promotes cell-cell contacts and plays important roles in the development of the nervous system (PubMed:21325282). Acts by forming homophilic or heterophilic trans- dimers (PubMed:21325282). Heterophilic interactions have been detected between NECTIN1 and NECTIN3 and between NECTIN1 and NECTIN4 (By similarity). Involved in axon guidance by promoting contacts between the commissural axons and the floor plate cells (By similarity). Involved in synaptogegesis (By similarity). Has some neurite outgrowth- promoting activity (By similarity). Promotes formation of checkerboard- like cellular pattern of hair cells and supporting cells in the auditory epithelium via heterophilic interaction with NECTIN3: NECTIN1 is present in the membrane of hair cells and associates with NECTIN3 on supporting cells, thereby mediating heterotypic adhesion between these two cell types (By similarity). Required for enamel mineralization (By similarity). |
| Cellular Location | Cell membrane; Single-pass type I membrane protein. Cell junction, adherens junction. Presynaptic cell membrane {ECO:0000250|UniProtKB:Q9JKF6}; Single-pass type I membrane protein Note=In the auditory epithelium, specificaly localizes to the apical side of the lateral membranes of hair cells {ECO:0000250|UniProtKB:Q9JKF6} [Isoform Delta]: Cell membrane; Single-pass type I membrane protein |
Research Areas
Application Protocols
Provided below are standard protocols that you may find useful for product applications.
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Discontinued
Cat# ALS18330
Size:
50 µl
Price:
¥ 4,380.00
替代产品:
