Anti-ABCB10 Antibody (aa441-490)

Rabbit Anti Human Polyclonal Antibody

Product Information
Application Applications Legend: E=ELISA WB=Western Blotting IHC=Immunohistochemistry IHC-P=Immunohistochemistry (Paraffin) IP=Immunoprecipitation IF=Immunofluorescence IC=Immunochemistry ICC=Immunocytochemistry FC=Flow Cytometry DB=Dot Blot	WB, IHC-P, E
Primary Accession	Q9NRK6
Predicted	Human
Host	Rabbit
Clonality	Polyclonal
Isotype	IgG
Calculated MW	79148 Da

Additional Information
Gene ID	23456
Alias Symbol	ABCB10
Other Names	ABCB10, ABC-me, ABC transporter 10 protein, M-ABC2, EST20237, MTABC2
Target/Specificity	ABCB10 Antibody detects endogenous levels of total ABCB10 protein.
Reconstitution & Storage	Immunoaffinity purified
Precautions	Anti-ABCB10 Antibody (aa441-490) is for research use only and not for use in diagnostic or therapeutic procedures.

Protein Information
Name	ABCB10 (HGNC:41)
Function	ATP-dependent transporter located in the mitochondrial inner membrane that catalyzes the export of biliverdin from the mitochondrial matrix, and plays a crucial role in hemoglobin synthesis and antioxidative stress (PubMed:22085049, PubMed:28315685, PubMed:28808058, PubMed:34011630, PubMed:37041204). Participates in the early step of the heme biosynthetic process during insertion of iron into protoporphyrin IX (PPIX) (PubMed:22085049, PubMed:28808058). Involved in the stabilization of the iron transporter mitoferrin- 1/SLC25A37 (By similarity). In addition may be involved in mitochondrial unfolded protein response (UPRmt) signaling pathway, although ABCB10 probably does not participate in peptide export from mitochondria (PubMed:28315685).
Cellular Location	Mitochondrion inner membrane {ECO:0000250\|UniProtKB:Q9JI39}; Multi-pass membrane protein
Tissue Location	Ubiquitous. Highly expressed in bone marrow, expressed at intermediate to high levels in skeletal muscle, small intestine, thyroid, heart, brain, placenta, liver, pancreas, prostate, testis, ovary, leukocyte, stomach, spinal cord, lymph node, trachea and adrenal gland, and low levels are found in lung, kidney, spleen, thymus and colon.