癌症的基本特征包括细胞增殖、血管生成、迁移、凋亡逃避机制和细胞永生等。找到癌症发生过程中这些通路的关键标记物和对应的抗体用于检测至关重要。
为您推荐一个泛素化位点预测神器——泛素化分析工具，可以为您的蛋白的泛素化位点作出预测和评分。
细胞自噬受体图形绘图工具为你的蛋白的细胞受体结合位点作出预测和评分，识别结合到自噬通路中的蛋白是非常重要的，便于让我们理解自噬在正常生理、病理过程中的作用，如发育、细胞分化、神经退化性疾病、压力条件下、感染和癌症。
Anti-TNFRSF10B / Killer / DR5 Antibody (clone HS201)
Mouse Anti Human Monoclonal Antibody
- 产品详情
- 实验流程
Application 
| IHC-P, ICC, IP, FuncS, FC |
|---|---|
| Primary Accession | O14763 |
| Predicted | Human |
| Host | Mouse |
| Clonality | Monoclonal |
| Isotype | IgG1 |
| Clone Names | HS201 |
| Calculated MW | 47878 Da |
| Concentration (mg/ml) | 1 mg/ml |
| Gene ID | 8795 |
|---|---|
| Alias Symbol | TNFRSF10B |
| Other Names | TNFRSF10B, Cytotoxic TRAIL receptor-2, CD262 antigen, DR5, Death receptor 5, KILLER, TRAIL-R2, TRICK2B, TRAILR2, TRICK2A, TRICKB, TRICK2, CD262, Fas-like protein, TRAIL receptor 2, ZTNFR9 |
| Target/Specificity | Recognizes human TRAIL-R2. Does not cross-react with human TRAIL-R1, -R3 or -R4. |
| Reconstitution & Storage | Protein G purified |
| Precautions | Anti-TNFRSF10B / Killer / DR5 Antibody (clone HS201) is for research use only and not for use in diagnostic or therapeutic procedures. |
| Name | TNFRSF10B |
|---|---|
| Synonyms | DR5, KILLER, TRAILR2, TRICK2, ZTNFR9 |
| Function | Receptor for the cytotoxic ligand TNFSF10/TRAIL (PubMed:10549288). The adapter molecule FADD recruits caspase-8 to the activated receptor. The resulting death-inducing signaling complex (DISC) performs caspase-8 proteolytic activation which initiates the subsequent cascade of caspases (aspartate-specific cysteine proteases) mediating apoptosis. Promotes the activation of NF-kappa-B. Essential for ER stress-induced apoptosis. |
| Cellular Location | Membrane; Single-pass type I membrane protein. |
| Tissue Location | Widely expressed in adult and fetal tissues; very highly expressed in tumor cell lines such as HeLaS3, K-562, HL-60, SW480, A-549 and G-361; highly expressed in heart, peripheral blood lymphocytes, liver, pancreas, spleen, thymus, prostate, ovary, uterus, placenta, testis, esophagus, stomach and throughout the intestinal tract; not detectable in brain |
Research Areas
For Research Use Only. Not For Use In Diagnostic Procedures.
Application Protocols
Provided below are standard protocols that you may find useful for product applications.
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Discontinued
Cat# ALS18383
