癌症的基本特征包括细胞增殖、血管生成、迁移、凋亡逃避机制和细胞永生等。找到癌症发生过程中这些通路的关键标记物和对应的抗体用于检测至关重要。
为您推荐一个泛素化位点预测神器——泛素化分析工具，可以为您的蛋白的泛素化位点作出预测和评分。
细胞自噬受体图形绘图工具为你的蛋白的细胞受体结合位点作出预测和评分，识别结合到自噬通路中的蛋白是非常重要的，便于让我们理解自噬在正常生理、病理过程中的作用，如发育、细胞分化、神经退化性疾病、压力条件下、感染和癌症。
Anti-KRT19 / CK19 / Cytokeratin 19 Antibody (Internal)
Rabbit Anti Human Polyclonal Antibody
- 产品详情
- 实验流程
Application 
| WB, IHC-P, IF, ICC |
|---|---|
| Primary Accession | P08727 |
| Predicted | Human, Pig |
| Host | Rabbit |
| Clonality | Polyclonal |
| Calculated MW | 44106 Da |
| Concentration (mg/ml) | 1 mg/ml |
| Gene ID | 3880 |
|---|---|
| Alias Symbol | KRT19 |
| Other Names | KRT19, CK19, Cytokeratin 19, Cytokeratin-19, Keratin 19, Keratin-19, CK-19, K19, K1CS, Keratin, type I, 40-kd |
| Target/Specificity | Recognizes endogenous levels of Cytokeratin 19 protein. |
| Reconstitution & Storage | Immunoaffinity purified |
| Precautions | Anti-KRT19 / CK19 / Cytokeratin 19 Antibody (Internal) is for research use only and not for use in diagnostic or therapeutic procedures. |
For Research Use Only. Not For Use In Diagnostic Procedures.
| Name | KRT19 (HGNC:6436) |
|---|---|
| Function | Structural component of intermediate filaments in epithelial cells. Forms intermediate filaments by heterodimerizing with the type II keratin KRT8, providing mechanical integrity to epithelial cells (PubMed:16000376). Integrates into the intermediate filament network of skeletal muscle fibers alongside desmin and KRT18, contributing to force transmission (By similarity). Specifically interacts with the actin-binding domain of dystrophin, helping to link the contractile apparatus to dystrophin at the costameres of striated muscle (PubMed:16000376). |
| Tissue Location | Expressed in a defined zone of basal keratinocytes in the deep outer root sheath of hair follicles. Also observed in sweat gland and mammary gland ductal and secretory cells, bile ducts, gastrointestinal tract, bladder urothelium, oral epithelia, esophagus, ectocervical epithelium (at protein level). Expressed in epidermal basal cells, in nipple epidermis and a defined region of the hair follicle. Also seen in a subset of vascular wall cells in both the veins and artery of human umbilical cord, and in umbilical cord vascular smooth muscle. Observed in muscle fibers accumulating in the costameres of myoplasm at the sarcolemma in structures that contain dystrophin and spectrin. |
Research Areas
Application Protocols
Provided below are standard protocols that you may find useful for product applications.
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