癌症的基本特征包括细胞增殖、血管生成、迁移、凋亡逃避机制和细胞永生等。找到癌症发生过程中这些通路的关键标记物和对应的抗体用于检测至关重要。
为您推荐一个泛素化位点预测神器——泛素化分析工具，可以为您的蛋白的泛素化位点作出预测和评分。
细胞自噬受体图形绘图工具为你的蛋白的细胞受体结合位点作出预测和评分，识别结合到自噬通路中的蛋白是非常重要的，便于让我们理解自噬在正常生理、病理过程中的作用，如发育、细胞分化、神经退化性疾病、压力条件下、感染和癌症。
Anti-ATP2B2 / PMCA2 Antibody (Internal)
Rabbit Anti Human Polyclonal Antibody
- 产品详情
- 实验流程
Application 
| WB, IHC-P |
|---|---|
| Primary Accession | Q01814 |
| Predicted | Human, Mouse, Rat |
| Host | Rabbit |
| Clonality | Polyclonal |
| Calculated MW | 136876 Da |
| Concentration (mg/ml) | 1 mg/ml |
| Gene ID | 491 |
|---|---|
| Alias Symbol | ATP2B2 |
| Other Names | ATP2B2, PMCA2, Plasma membrane calcium ATPase, PMCA2i, Plasma membrane Ca2+ pump 2, Plasma membrane calcium pump, Plasma membrane Ca(2+)-ATPase, PMCA2a |
| Target/Specificity | Recognizes endogenous levels of PMCA2 protein. |
| Reconstitution & Storage | Immunoaffinity purified |
| Precautions | Anti-ATP2B2 / PMCA2 Antibody (Internal) is for research use only and not for use in diagnostic or therapeutic procedures. |
For Research Use Only. Not For Use In Diagnostic Procedures.
| Name | ATP2B2 {ECO:0000303|PubMed:15829536, ECO:0000312|HGNC:HGNC:815} |
|---|---|
| Function | ATP-driven Ca(2+) ion pump involved in the maintenance of basal intracellular Ca(2+) levels in specialized cells of cerebellar circuit and vestibular and cochlear systems (PubMed:15829536, PubMed:17234811). Uses ATP as an energy source to transport cytosolic Ca(2+) ions across the plasma membrane to the extracellular compartment (PubMed:15829536, PubMed:17234811). Has fast activation and Ca(2+) clearance rate suited to control fast neuronal Ca(2+) dynamics. At parallel fiber to Purkinje neuron synapse, mediates presynaptic Ca(2+) efflux in response to climbing fiber-induced Ca(2+) rise. Provides for fast return of Ca(2+) concentrations back to their resting levels, ultimately contributing to long-term depression induction and motor learning (By similarity). Plays an essential role in hearing and balance (PubMed:15829536, PubMed:17234811). In cochlear hair cells, shuttles Ca(2+) ions from stereocilia to the endolymph and dissipates Ca(2+) transients generated by the opening of the mechanoelectrical transduction channels. Regulates Ca(2+) levels in the vestibular system, where it contributes to the formation of otoconia (PubMed:15829536, PubMed:17234811). In non-excitable cells, regulates Ca(2+) signaling through spatial control of Ca(2+) ions extrusion and dissipation of Ca(2+) transients generated by store-operated channels (PubMed:25690014). In lactating mammary gland, allows for the high content of Ca(2+) ions in the milk (By similarity). |
| Cellular Location | Cell membrane; Multi-pass membrane protein. Synapse {ECO:0000250|UniProtKB:Q9R0K7} [Isoform WB]: Apical cell membrane; Multi-pass membrane protein {ECO:0000250|UniProtKB:Q9R0K7}. Basolateral cell membrane; Multi-pass membrane protein {ECO:0000250|UniProtKB:Q9R0K7} [Isoform ZA]: Basolateral cell membrane; Multi-pass membrane protein {ECO:0000250|UniProtKB:Q9R0K7} |
| Tissue Location | Mainly expressed in brain cortex. Found in low levels in skeletal muscle, heart muscle, stomach, liver, kidney and lung. Isoforms containing segment B are found in brain cortex and at low levels in other tissues. Isoforms containing segments X and W are found at low levels in all tissues. Isoforms containing segment A and segment Z are found at low levels in skeletal muscle and heart muscle |
Research Areas
Application Protocols
Provided below are standard protocols that you may find useful for product applications.
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