Anti-GLRA1/Glycine Receptor Alpha 1 Antibody (N-Terminus)

Rabbit Anti Human Polyclonal Antibody

Product Information
Application Applications Legend: E=ELISA WB=Western Blotting IHC=Immunohistochemistry IHC-P=Immunohistochemistry (Paraffin) IP=Immunoprecipitation IF=Immunofluorescence IC=Immunochemistry ICC=Immunocytochemistry FC=Flow Cytometry DB=Dot Blot	WB, IHC-P
Primary Accession	P23415
Predicted	Human, Mouse
Host	Rabbit
Clonality	Polyclonal
Calculated MW	52624 Da

Additional Information
Gene ID	2741
Alias Symbol	GLRA1
Other Names	GLRA1, Alpha 1 glycine Receptor, GlyR alpha 1, GLYRA1, SPD, STHE, Spasmodic, Glycine receptor alpha 1, Glycine receptor, alpha 1, HKPX1, Strychnine binding subunit
Target/Specificity	Endogenous levels of mouse alpha 1 Glycine Receptor. It is predicted to react with human alpha 1 Glycine Receptor according to sequence homology. Positive Control: Mouse brain.
Reconstitution & Storage	Immunoaffinity purified
Precautions	Anti-GLRA1/Glycine Receptor Alpha 1 Antibody (N-Terminus) is for research use only and not for use in diagnostic or therapeutic procedures.

Protein Information
Name	GLRA1
Function	Subunit of heteromeric glycine-gated chloride channels (PubMed:14551753, PubMed:23994010, PubMed:25730860, PubMed:37821459). Plays an important role in the down-regulation of neuronal excitability (PubMed:8298642, PubMed:9009272). Contributes to the generation of inhibitory postsynaptic currents (PubMed:25445488). Channel activity is potentiated by ethanol (PubMed:25973519). Potentiation of channel activity by intoxicating levels of ethanol contribute to the sedative effects of ethanol (By similarity).
Cellular Location	Postsynaptic cell membrane {ECO:0000250\|UniProtKB:Q64018}; Multi-pass membrane protein {ECO:0000250\|UniProtKB:Q64018}. Synapse {ECO:0000250\|UniProtKB:Q64018} Perikaryon {ECO:0000250\|UniProtKB:Q64018}. Cell projection, dendrite {ECO:0000250\|UniProtKB:Q64018}. Cell membrane; Multi-pass membrane protein