癌症的基本特征包括细胞增殖、血管生成、迁移、凋亡逃避机制和细胞永生等。找到癌症发生过程中这些通路的关键标记物和对应的抗体用于检测至关重要。
为您推荐一个泛素化位点预测神器——泛素化分析工具，可以为您的蛋白的泛素化位点作出预测和评分。
细胞自噬受体图形绘图工具为你的蛋白的细胞受体结合位点作出预测和评分，识别结合到自噬通路中的蛋白是非常重要的，便于让我们理解自噬在正常生理、病理过程中的作用，如发育、细胞分化、神经退化性疾病、压力条件下、感染和癌症。
Anti-MARCH1 Antibody (Internal)
Rabbit Anti Human Polyclonal Antibody
- 产品详情
- 实验流程
Application 
| WB, IHC-P |
|---|---|
| Primary Accession | Q8TCQ1 |
| Predicted | Human, Mouse |
| Host | Rabbit |
| Clonality | Polyclonal |
| Calculated MW | 32308 Da |
| Concentration (mg/ml) | 1 mg/ml |
| Gene ID | 55016 |
|---|---|
| Alias Symbol | MARCH1 |
| Other Names | MARCH1, MARCH-I, RING finger protein 171, RNF171 |
| Target/Specificity | Recognizes endogenous levels of 42064 protein. |
| Reconstitution & Storage | Immunoaffinity purified |
| Precautions | Anti-MARCH1 Antibody (Internal) is for research use only and not for use in diagnostic or therapeutic procedures. |
For Research Use Only. Not For Use In Diagnostic Procedures.
| Name | MARCHF1 (HGNC:26077) |
|---|---|
| Synonyms | MARCH1, RNF171 |
| Function | E3 ubiquitin-protein ligase that mediates ubiquitination of TFRC, CD86, FAS and MHC class II proteins, such as HLA-DR alpha and beta, and promotes their subsequent endocytosis and sorting to lysosomes via multivesicular bodies (PubMed:18389477, PubMed:18305173, PubMed:21220452, PubMed:35045264). By constitutively ubiquitinating MHC class II proteins in immature dendritic cells, down-regulates their cell surface localization thus sequestering them in the intracellular endosomal system. Also regulates insulin sensitivity by controlling surface expression of the insulin receptor subunit beta/INSR by direct ubiquitination and degradation (PubMed:27577745). |
| Cellular Location | Golgi apparatus, trans-Golgi network membrane {ECO:0000250|UniProtKB:Q6NZQ8}; Multi-pass membrane protein. Lysosome membrane; Multi- pass membrane protein. Cytoplasmic vesicle membrane; Multi-pass membrane protein. Late endosome membrane; Multi-pass membrane protein. Early endosome membrane; Multi-pass membrane protein. Cell membrane; Multi-pass membrane protein |
| Tissue Location | Expressed in antigen presenting cells, APCs, located in lymph nodes and spleen. Also expressed in lung. Expression is high in follicular B-cells, moderate in dendritic cells and low in splenic T-cells. |
Research Areas
Application Protocols
Provided below are standard protocols that you may find useful for product applications.
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Discontinued
Cat# ALS18484
Size:
50 µl
Price:
¥ 4,380.00
替代产品:
