Anti-NFKBIE / IKB Epsilon Antibody (Internal)

Rabbit Anti Human Polyclonal Antibody

Product Information
Application Applications Legend: E=ELISA WB=Western Blotting IHC=Immunohistochemistry IHC-P=Immunohistochemistry (Paraffin) IP=Immunoprecipitation IF=Immunofluorescence IC=Immunochemistry ICC=Immunocytochemistry FC=Flow Cytometry DB=Dot Blot	WB, IHC-P, IF, ICC
Primary Accession	O00221
Predicted	Human, Mouse, Rat, Bovine
Host	Rabbit
Clonality	Polyclonal
Calculated MW	52864 Da
Concentration (mg/ml)	1 mg/ml

Additional Information
Gene ID	4794
Alias Symbol	NFKBIE
Other Names	NFKBIE, I-kappa-B-epsilon, IkappaBepsilon, IKB Epsilon, IkB-epsilon, NF-kappa-BIE, IkB-E, NF-kappa-B inhibitor epsilon, IKBE
Target/Specificity	Recognizes endogenous levels of IKB epsilon protein.
Reconstitution & Storage	Immunoaffinity purified
Precautions	Anti-NFKBIE / IKB Epsilon Antibody (Internal) is for research use only and not for use in diagnostic or therapeutic procedures.

Protein Information
Name	NFKBIE
Synonyms	IKBE
Function	Sequesters NF-kappa-B transcription factor complexes in the cytoplasm, thereby inhibiting their activity (PubMed:9315679). Sequestered complexes include NFKB1-RELA (p50-p65) and NFKB1-REL (p50- c-Rel) complexes (PubMed:9135156, PubMed:9315679). Limits B-cell activation in response to pathogens, and also plays an important role in B-cell development (By similarity).
Cellular Location	Cytoplasm.
Tissue Location	Highly expressed in spleen, testis and lung, followed by kidney, pancreas, heart, placenta and brain. Also expressed in granulocytes and macrophages