癌症的基本特征包括细胞增殖、血管生成、迁移、凋亡逃避机制和细胞永生等。找到癌症发生过程中这些通路的关键标记物和对应的抗体用于检测至关重要。
为您推荐一个泛素化位点预测神器——泛素化分析工具，可以为您的蛋白的泛素化位点作出预测和评分。
细胞自噬受体图形绘图工具为你的蛋白的细胞受体结合位点作出预测和评分，识别结合到自噬通路中的蛋白是非常重要的，便于让我们理解自噬在正常生理、病理过程中的作用，如发育、细胞分化、神经退化性疾病、压力条件下、感染和癌症。
Phospho-mBad(Ser155) Antibody
Purified Phospho-specific Monoclonal Antibody (Mab)
- 产品详情
- 实验流程
Application 
| WB, E |
|---|---|
| Primary Accession | Q61337 |
| Other Accession | NP_031548 |
| Reactivity | Mouse, Rat, Human |
| Host | Mouse |
| Clonality | Monoclonal |
| Isotype | Mouse IgG1 |
| Clone Names | 27AT381 |
| Calculated MW | 22080 Da |
| Gene ID | 12015 |
|---|---|
| Other Names | Bcl2-associated agonist of cell death, BAD, Bcl-2-binding component 6, Bcl-xL/Bcl-2-associated death promoter, Bcl2 antagonist of cell death, Bad, Bbc6 |
| Target/Specificity | This mouse Bad Antibody is generated from mice immunized with a KLH conjugated synthetic phosphopeptide corresponding to amino acid residues surrounding Ser155 of mouse Bad. |
| Dilution | WB~~1:500~1000 E~~Use at an assay dependent concentration. |
| Format | fomat Purified monoclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein G column, followed by dialysis against PBS. |
| Storage | Maintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles. |
| Precautions | Phospho-mBad(Ser155) Antibody is for research use only and not for use in diagnostic or therapeutic procedures. |
| Name | Bad |
|---|---|
| Synonyms | Bbc6 |
| Function | Promotes cell death. Successfully competes for the binding to Bcl-X(L), Bcl-2 and Bcl-W, thereby affecting the level of heterodimerization of these proteins with BAX. Can reverse the death repressor activity of Bcl-X(L), but not that of Bcl-2. Appears to act as a link between growth factor receptor signaling and the apoptotic pathways. |
| Cellular Location | Mitochondrion outer membrane. Cytoplasm. Note=Colocalizes with HIF3A isoform 2 in the cytoplasm (PubMed:21546903). Upon phosphorylation, locates to the cytoplasm. |
For Research Use Only. Not For Use In Diagnostic Procedures.
Provided below are standard protocols that you may find useful for product applications.
REFERENCES
Suppression of B-cell lymphomagenesis by the BH3-only proteins Bmf and Bad. Frenzel A, et al. Blood, 2010 Feb 4. PMID 19965635.
GLP-1 mediates antiapoptotic effect by phosphorylating Bad through a beta-arrestin 1-mediated ERK1/2 activation in pancreatic beta-cells. Quoyer J, et al. J Biol Chem, 2010 Jan 15. PMID 19915011.
Identification of novel in vivo phosphorylation sites of the human proapoptotic protein BAD: pore-forming activity of BAD is regulated by phosphorylation. Polzien L, et al. J Biol Chem, 2009 Oct 9. PMID 19667065.
Perinatal survivin is essential for the establishment of pancreatic beta cell mass in mice. Wu X, et al. Diabetologia, 2009 Oct. PMID 19644667.
MEK/ERK-mediated phosphorylation of Bim is required to ensure survival of T and B lymphocytes during mitogenic stimulation. O'Reilly LA, et al. J Immunol, 2009 Jul 1. PMID 19542438.
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