癌症的基本特征包括细胞增殖、血管生成、迁移、凋亡逃避机制和细胞永生等。找到癌症发生过程中这些通路的关键标记物和对应的抗体用于检测至关重要。
为您推荐一个泛素化位点预测神器——泛素化分析工具，可以为您的蛋白的泛素化位点作出预测和评分。
细胞自噬受体图形绘图工具为你的蛋白的细胞受体结合位点作出预测和评分，识别结合到自噬通路中的蛋白是非常重要的，便于让我们理解自噬在正常生理、病理过程中的作用，如发育、细胞分化、神经退化性疾病、压力条件下、感染和癌症。
HSPA1A Antibody
Mouse Monoclonal Antibody (Mab)
- 产品详情
- 实验流程
- 背景知识
Application 
| WB, IF, E |
|---|---|
| Primary Accession | P08107 |
| Other Accession | Q6S4N2, Q27965, P34930, Q27975, NP_005336.3 |
| Reactivity | Human |
| Predicted | Bovine, Pig |
| Host | Mouse |
| Clonality | Monoclonal |
| Isotype | IgG1,K |
| Clone Names | 201CT8.2.3 |
| Antigen Region | 574-600 aa |
| Other Names | Heat shock 70 kDa protein 1A/1B, Heat shock 70 kDa protein 1/2, HSP70-1/HSP70-2, HSP701/HSP702, HSPA1A, HSPA1, HSX70 |
|---|---|
| Target/Specificity | This HSPA1A antibody is generated from mice immunized with a KLH conjugated synthetic peptide between 574-600 amino acids from human HSPA1A. |
| Dilution | WB~~1:100~2000 IF~~1:10~50 E~~Use at an assay dependent concentration. |
| Format | Purified monoclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein G column, followed by dialysis against PBS. |
| Storage | Maintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles. |
| Precautions | HSPA1A Antibody is for research use only and not for use in diagnostic or therapeutic procedures. |
For Research Use Only. Not For Use In Diagnostic Procedures.
Provided below are standard protocols that you may find useful for product applications.
BACKGROUND
This intronless gene encodes a 70kDa heat shock protein which is a member of the heat shock protein 70 family. In conjuction with other heat shock proteins, this protein stabilizes existing proteins against aggregation and mediates the folding of newly translated proteins in the cytosol and in organelles. It is also involved in the ubiquitin-proteasome pathway through interaction with the AU-rich element RNA-binding protein 1. The gene is located in the major histocompatibility complex class III region, in a cluster with two closely related genes which encode similar proteins.
REFERENCES
Wang, Y., et al. Clin. Chem. Lab. Med. 48(11):1657-1663(2010)
Eisenberg, D.P., et al. Surgery 148(2):325-334(2010)
Rusai, K., et al. Transplant. Proc. 42(6):2309-2311(2010)
Ebrahimi, M., et al. Mol. Vis. 16, 1680-1688 (2010) :
Lanneau, D., et al. ScientificWorldJournal 10, 1543-1552 (2010) :
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