癌症的基本特征包括细胞增殖、血管生成、迁移、凋亡逃避机制和细胞永生等。找到癌症发生过程中这些通路的关键标记物和对应的抗体用于检测至关重要。
为您推荐一个泛素化位点预测神器——泛素化分析工具，可以为您的蛋白的泛素化位点作出预测和评分。
细胞自噬受体图形绘图工具为你的蛋白的细胞受体结合位点作出预测和评分，识别结合到自噬通路中的蛋白是非常重要的，便于让我们理解自噬在正常生理、病理过程中的作用，如发育、细胞分化、神经退化性疾病、压力条件下、感染和癌症。
CDC25C Antibody (ascites)
Mouse Monoclonal Antibody (Mab)
- 产品详情
- 实验流程
- 背景知识
Application 
| WB, E |
|---|---|
| Primary Accession | P30307 |
| Other Accession | NP_001781.2, NP_073720.1 |
| Reactivity | Human |
| Host | Mouse |
| Clonality | Monoclonal |
| Isotype | IgG1,k |
| Clone Names | 233CT9.6.6 |
| Calculated MW | 53365 Da |
| Gene ID | 995 |
|---|---|
| Other Names | M-phase inducer phosphatase 3, Dual specificity phosphatase Cdc25C, CDC25C |
| Target/Specificity | This CDC25C monoclonal antibody is generated from mouse immunized with CDC25C recombinant protein. |
| Dilution | WB~~1:1000~8000 E~~Use at an assay dependent concentration. |
| Format | Mouse monoclonal antibody supplied in crude ascites with 0.09% (W/V) sodium azide. |
| Storage | Maintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles. |
| Precautions | CDC25C Antibody (ascites) is for research use only and not for use in diagnostic or therapeutic procedures. |
| Name | CDC25C |
|---|---|
| Function | Functions as a dosage-dependent inducer in mitotic control. Tyrosine protein phosphatase required for progression of the cell cycle (PubMed:8119945). When phosphorylated, highly effective in activating G2 cells into prophase (PubMed:8119945). Directly dephosphorylates CDK1 and activates its kinase activity (PubMed:8119945). |
| Cellular Location | Nucleus |
For Research Use Only. Not For Use In Diagnostic Procedures.
Provided below are standard protocols that you may find useful for product applications.
BACKGROUND
This gene is highly conserved during evolution and it plays a key role in the regulation of cell division. The encoded protein is a tyrosine phosphatase and belongs to the Cdc25 phosphatase family. It directs dephosphorylation of cyclin B-bound CDC2 and triggers entry into mitosis. It is also thought to suppress p53-induced growth arrest. Multiple alternatively spliced transcript variants of this gene have been described, however, the full-length nature of many of them is not known. [provided by RefSeq].
REFERENCES
Moon, D.O., et al. Oncol. Rep. 24(1):271-276(2010) Liu, C.Y., et al. Carcinogenesis 31(7):1259-1263(2010) Olson, J.E., et al. Breast Cancer Res. Treat. (2010) In press : Franckhauser, C., et al. PLoS ONE 5 (7), E11798 (2010) : Wang, Z., et al. BMC Cancer 10, 233 (2010) :
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